Spatial memory testing decreases hippocampal amyloid precursor protein in young, but not aged, female rats

被引：24

作者：

Bimonte, HA

Granholm, ACE

Seo, H

Isacson, O

机构：

[1] Med Univ S Carolina, Dept Physiol & Neurosci, Charleston, SC 29425 USA

[2] Med Univ S Carolina, Ctr Studies Aging, Charleston, SC 29425 USA

[3] Harvard Univ, McLean Hosp, Sch Med, Neuroregenerat Lab, Belmont, MA 02478 USA

来源：

NEUROSCIENCE LETTERS | 2002年 / 328卷 / 01期

关键词：

amyloid precursor protein; radial arm; aging; working memory; learning; hippocampus;

D O I：

10.1016/S0304-3940(02)00442-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Using young and aged rats, we investigated relationships between amyloid precursor protein (APP) and working or reference memory, as well as assessed whether cognitive testing altered APP levels. In young rats, higher APP levels were related to more working memory errors as a linear function. Aged rats exhibited a curvilinear relationship between APP and working memory, with moderate APP levels associated with better relative performance. A comparison of rats that received cognitive testing with those that did not showed that testing decreased APP levels in young, but not aged, rats. Collectively, the data suggest that young and aged rats exhibit different relationships between APP and working memory, and that aged rats do not maintain the capacity to decrease APP in response to cognitive testing. (C) 2002 Published by Elsevier Science Ireland Ltd.

引用

页码：50 / 54

页数：5

共 22 条

[1]

AGE AND DAMAGE-INDUCED CHANGES IN AMYLOID PROTEIN-PRECURSOR IMMUNOHISTOCHEMISTRY IN THE RAT-BRAIN [J].