New amino acid porphyrin derivatives .2. DNA binding studies

被引：16

作者：

VerchereBeaur, C ^{[1
]}

PerreeFauvet, M ^{[1
]}

Tarnaud, E ^{[1
]}

AnneheimHerbelin, G ^{[1
]}

Bone, N ^{[1
]}

Gaudemer, A ^{[1
]}

机构：

[1] UNIV PARIS 11,INST CHIM MOL ORSAY,CNRS,LAB CHIM BIOORGAN & BIOINORGAN,F-91405 ORSAY,FRANCE

来源：

TETRAHEDRON | 1996年 / 52卷 / 43期

关键词：

D O I：

10.1016/0040-4020(96)00833-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Binding to a variety of natural and synthetic DNAs by cationic water-soluble porphyrins having three N-methylpyridynium and one amino-acid derivatized phenyl ring as meso substituents - has been investigated. These studies indicate that amino acid porphyrin derivatives are able to intercalate into calf thymus DNA, but not as readily as meso-tetrakis-(N-methyl-4-pyridiniumyl)porphyrin (H(2)TMPyP-4). This lowering of affinity for intercalation may be due to the presence of only three positive charges on the porphyrin ion and/or an increased specificity towards specific DNA sequences arising from amino acid linkage. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：13589 / 13604

页数：16

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