Biocatalysis in organic synthesis: The use of nitrile- and amide-hydrolyzing microorganisms

被引：127

作者：

Sugai, T

Yamazaki, T

Yokoyama, M

Ohta, H

机构：

[1] Department of Chemistry, Keio University, Yokohama, 223

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1997年 / 61卷 / 09期

关键词：

nitrile; amide; hydrolysis; microorganisms; organic synthesis;

D O I：

10.1271/bbb.61.1419

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review covers recent examples of synthetic transformation of nitriles and amides by microbial enzyme systems. A variety of substrates and products involving enantiomerically enriched forms of chiral substances are referred to. The stereochemical course of enzyme-catalyzed hydrolysis is briefly commented on. Special emphasis is placed upon the range of functional groups that are acceptable by enzymes and/or survive under the transformation, as well as the advantages as a synthetic tool for conversion under mild conditions.

引用

页码：1419 / 1427

页数：9

共 100 条

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ARNAUD A, 1980, B SOC CHIM FR II-CH, P87

[2]

ASANO Y, 1989, J BIOL CHEM, V264, P14233

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