Simulation of domain formation in DLPC-DSPC mixed bilayers

被引:89
作者
Faller, R [1 ]
Marrink, SJ
机构
[1] Univ Calif Davis, Dept Chem Engn & Mat Sci, Davis, CA 95616 USA
[2] Univ Groningen, Dept Biophys Chem, Groningen, Netherlands
关键词
D O I
10.1021/la0492759
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Binary mixtures of two phosphatidylcholines of different chain lengths are simulated in the bilayer state. We find a phase transition between a liquid state and a gel state at all concentrations. This phase transition is characterized by the area per lipid headgroup, the order parameter, and a change in dynamics. At concentrations with a majority of the longer lipid, we find phase separation into a gel and a liquid state in a small temperature window. This leads to a strong dynamic heterogeneity. Experimental phase transition temperatures are reproduced semiquantitatively. We see a clear shift in the phase transition to higher temperatures with increasing concentration of the longer lipid.
引用
收藏
页码:7686 / 7693
页数:8
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