Nucleophilic trifluoromethylation of acyl chlorides using the trifluoromethyl iodide/TDAE reagent

被引：61

作者：

Takechi, N

Aït-Mohand, S

Médebielle, M

Dolbier, WR ^{[1
]}

机构：

[1] Univ Florida, Dept Chem, Gainesville, FL 32611 USA

[2] Univ Lyon 1, Lab SECOF, UMR CNRS 5622, F-69622 Villeurbanne, France

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 24期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(02)00800-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chemoselective bis-trifluoromethylation of acyl chlorides using the CF3I/TDAE-derived nucleophilic trifluoromethyl anion reagent is reported. Very high yields are obtained of an ester product formed by sequential nucleophilic bis-trifluoromethylation, followed by acylation of the resultant alcoholate. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：4317 / 4319

页数：3

共 6 条

[1]

Chambers RD, 1997, TOP CURR CHEM, V192, P1

[2] PREPARATION OF TRIFLUOROMETHYL AND OTHER PERFLUOROALKYL COMPOUNDS WITH (PERFLUORALKYL)TRIMETHYLSILANES [J].