Enantioselective syntheses of nonracemic benzyl-α-d alcohols via catalytic transfer-hydrogenation with Ru, Os, Rh, and Ir catalysts

被引：30

作者：

Faller, JW ^{[1
]}

Lavoie, AR ^{[1
]}

机构：

[1] Yale Univ, Dept Chem, New Haven, CT 06520 USA

来源：

ORGANOMETALLICS | 2002年 / 21卷 / 16期

关键词：

D O I：

10.1021/om020058h

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis of chiral benzyl-a-d alcohols via the reduction of benialdehyde-a-d derivatives has been investigated with a. series of catalysts that were derived in situ from (1R,2S)- (+)-cis-1-amino-2-indanol and the chloro-bridged dimers of p-cymeneRu, p-cymeneOs, Cp*Rh, or Cp*Ir. An unusual trend was observed in which substrates containing electron-withdrawing substituents led to greater enantioenrichment than those with electron-donating substituents., All four catalyst systems were found to produce benzyl-a-d alcohols with high conversion (>98%). Modest to good enantioselectivites (up to 68% ee) were observed.

引用

页码：3493 / 3495

页数：3

共 27 条

[1] Chiral platinum and palladium complexes containing functionalized C2-symmetric bisaminoaryl 'Pincer' ligands [J].