Chaetocochins A-C, epipolythiodioxopiperazines from Chaetomium cochliodes

被引：70

作者：

Li, Guo-You

Li, Bo-Gang

Yang, Tao

Yan, Ju-Fang

Liu, Guang-Ye

Zhang, Guo-Lin ^{[1
]}

机构：

[1] Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

[3] Chengdu Di Ao Pharmaceut Grp, Inst Pharmaceut, Chengdu 610041, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 09期

关键词：

D O I：

10.1021/np0602970

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new epipolythiodioxopiperazines, chaetocochins A ( 1), B ( 2), and C ( 3), along with dethio-tetra ( methylthio) chetomin ( 4) and chetomin ( 5), were isolated from the ethyl acetate extract of the solid-state fermented rice culture of the fungus Chaetomium cochliodes. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 1, 3, and 4 exhibited significant cytotoxicity in vitro against cancer cell lines Bre-04, Lu-04, and N-04.

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页码：1374 / 1376

页数：3

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