Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: A French community-based study

被引:234
作者
Berr, C
Lafont, S
Debuire, B
Dartigues, JF
Baulieu, EE
机构
[1] UNIV BORDEAUX 2, INSERM U330, F-33076 BORDEAUX, FRANCE
[2] HOP PAUL BROUSSE, SERV BIOCHIM, F-94808 VILLEJUIF, FRANCE
[3] HOP BICETRE, INSERM U33, F-94276 LE KREMLIN BICETRE, FRANCE
关键词
D O I
10.1073/pnas.93.23.13410
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
In human beings of both sexes, dehydroepiandrosterone sulfate (DHEAS) circulating in blood is mostly an adrenally secreted steroid whose serum concentration (in the micromolar range and 30-50% higher in men than in women) decreases with age, toward approximate to 20-10% of its value in young adults during the 8th and 9th decades. The mechanism of action of DHEA and DHEAS is poorly known and may include partial transformation into sex steroids, increase of bioavailable insulin-like growth factor I, and effects on neurotransmitter receptors. Whether there is a cause-to-effect relationship between the decreasing levels of DHEAS with age and physiological and pathological manifestations of aging is still undecided, but this is of obvious theoretical and practical interest in view of the easy restoration by DHEAS administration. Here we report on 622 subjects over 65 years of age, studied for the 4 years since DHEAS baseline values had been obtained, in the frame of the PAQUID program, analyzing the functional, psychological, and mental status of a community-based population in the south-west of France. We confirm the continuing decrease of DHEAS serum concentration with age, more in men than in women, even if men retain higher levels. Significantly lower values of baseline DHEAS were recorded in women in cases of functional limitation (Instrumental Activities of Daily Living), confinement, dyspnea, depressive symptomatology, poor subjective perception of health and life satisfaction, and usage of various medications. In men, there was a trend for the same correlations, even though not statistically significant in most categories. No differences in DHEAS levels were found in cases of incident dementia in the following 4 years. In men (but not in women), lower DHEAS was significantly associated with increased short-term mortality at 2 and 4 years after baseline measurement. These results, statistically established by taking into account corrections for age, sex, and health indicators, suggest the need for further careful trials of the administration of replacement doses of DHEA in aging humans. Indeed, the first noted results of such ''treatment'' are consistent with correlations observed here between functional and psychological status and endogenous steroid serum concentrations.
引用
收藏
页码:13410 / 13415
页数:6
相关论文
共 50 条
[1]  
[Anonymous], 1987, DIAGNOSTIC STAT MANU, V4th
[2]  
[Anonymous], 1980, International classification of impairments, disabilities and handicaps
[3]   HEALTH MEASURES CORRELATES IN A FRENCH ELDERLY COMMUNITY POPULATION - THE PAQUID STUDY [J].
BARBERGERGATEAU, P ;
CHASLERIE, A ;
DARTIGUES, JF ;
COMMENGES, D ;
GAGNON, M ;
SALAMON, R .
JOURNALS OF GERONTOLOGY, 1992, 47 (02) :S88-S95
[4]   A PROSPECTIVE-STUDY OF DEHYDROEPIANDROSTERONE-SULFATE AND COGNITIVE FUNCTION IN AN OLDER POPULATION - THE RANCHO-BERNARDO STUDY [J].
BARRETTCONNOR, E ;
EDELSTEIN, SL .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1994, 42 (04) :420-423
[5]   DEHYDROEPIANDROSTERONE-SULFATE DOES NOT PREDICT CARDIOVASCULAR DEATH IN POSTMENOPAUSAL WOMEN - THE RANCHO-BERNARDO STUDY [J].
BARRETTCONNOR, E ;
GOODMANGRUEN, D .
CIRCULATION, 1995, 91 (06) :1757-1760
[6]  
BARRETTCONNOR E, 1987, NEW ENGL J MED, V317, P711
[7]   A PROSPECTIVE-STUDY OF DEHYDROEPIANDROSTERONE SULFATE, MORTALITY, AND CARDIOVASCULAR-DISEASE [J].
BARRETTCONNOR, E ;
KHAW, KT ;
YEN, SSC .
NEW ENGLAND JOURNAL OF MEDICINE, 1986, 315 (24) :1519-1524
[8]  
BARRETTCONNOR E, 1996, ANN NY ACAD SCI, V774, P259
[9]   Dehydroepiandrosterone (DHEA): A fountain of youth? [J].
Baulieu, EE .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (09) :3147-3151
[10]  
BAULIEU ETIENNE-EMILE, 1965, RECENT PROG HORMONE RES, V21, P411