Metabotropic glutamate receptors

被引：417

作者：

Ferraguti, Francesco

Shigemoto, Ryuichi ^{[1
]}

机构：

[1] Natl Inst Physiol Sci, Div Cerebral Struct, Okazaki, Aichi 4448787, Japan

[2] Innsbruck Med Univ, Dept Pharmacol, A-6020 Innsbruck, Austria

来源：

CELL AND TISSUE RESEARCH | 2006年 / 326卷 / 02期

基金：

奥地利科学基金会;

关键词：

metabotropic glutamate receptor; immunohistochemistry; electron microscopy; central nervous system; peripheral localization;

D O I：

10.1007/s00441-006-0266-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Metabotropic glutamate receptors (mGlus) are a family of G-protein-coupled receptors activated by the neurotransmitter glutamate. Molecular cloning has revealed eight different subtypes (mGlu1-8) with distinct molecular and pharmacological properties. Multiplicity in this receptor family is further generated through alternative splicing. mGlus activate a multitude of signalling pathways important for modulating neuronal excitability, synaptic plasticity and feedback regulation of neurotransmitter release. In this review, we summarize anatomical findings (from our work and that of other laboratories) describing their distribution in the central nervous system. Recent evidence regarding the localization of these receptors in peripheral tissues will also be examined. The distinct regional, cellular and subcellular distribution of mGlus in the brain will be discussed in view of their relationship to neurotransmitter release sites and of possible functional implications.

引用

页码：483 / 504

页数：22

共 301 条

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