Uncinate fasciculus abnormalities in recent onset schizophrenia and affective psychosis: A diffusion tensor imaging study

被引:55
作者
Kawashima, Toshiro [1 ,2 ,3 ]
Nakamura, Motoaki [1 ,2 ]
Bouix, Sylvain [1 ]
Kubicki, Marek [1 ,2 ]
Salisbury, Dean F. [4 ]
Westin, Carl-Fredrik [5 ]
McCarley, Robert W. [2 ]
Shenton, Martha E. [1 ,2 ]
机构
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Psychiat,Psychiat Neuroimaging Lab, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Boston Vet Affairs Healthcare Syst,Clin Neurosci, Dept Psychiat,Brockton Div,Lab Neurosci, Brockton, MA 02301 USA
[3] Saga Univ, Fac Med, Dept Psychiat, Saga 8498501, Japan
[4] Harvard Univ, Sch Med, Dept Psychiat, McLean Hosp,Cognit Neurosci Lab, Belmont, MA 02478 USA
[5] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Radiol,Lab Math Imaging, Boston, MA 02115 USA
关键词
Diffusion tensor imaging; Schizophrenia; Affective psychosis; Uncinate fasciculus; Cingulum bundle; Fractional anisotropy; WHITE-MATTER INTEGRITY; 1ST-EPISODE AFFECTIVE PSYCHOSIS; MIDDLE CEREBELLAR PEDUNCLES; LEFT TEMPORAL-LOBE; CORPUS-CALLOSUM; AFFECTIVE-DISORDER; ANTERIOR CINGULUM; PREFRONTAL CORTEX; RHESUS-MONKEY; MRI;
D O I
10.1016/j.schres.2009.01.014
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Two of the most frequently investigated regions in diffusion tensor imaging studies in chronic schizophrenia are the uncinate fasciculus (UF) and cingulum bundle (CB). The purpose of the present study was to determine whether UF and CB white matter integrity were altered at the early stage of illness and specific to schizophrenia. Fifteen schizophrenia subjects and 15 affective psychosis within 4 years of first hospitalization (12 patients with schizophrenia and 12 patients with affective psychosis during their first hospitalization), and 15 psychiatrically healthy controls underwent line-scan diffusion tensor imaging. Fractional anisotropy (FA) and mean diffusivity (D-m) were used to quantify water diffusion, and cross-sectional area was defined with a directional threshold method. Bilaterally reduced FA, but not D-m, was present in the UF of schizophrenia compared with healthy controls. Affective psychosis was intermediate between schizophrenia subjects and healthy controls, but not significantly different from either. For CB, there was no significant group difference for FA or D-m. These findings suggest that UF, but not CB, white matter integrity is altered at the early stage of illness in schizophrenia although it may not be specific to schizophrenia. The CB abnormalities reported in chronic schizophrenia may develop during the later course of the disease. Published by Elsevier B.V.
引用
收藏
页码:119 / 126
页数:8
相关论文
共 54 条
[1]   Schizophrenia and cognitive dysmetria: A positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry [J].
Andreasen, NC ;
OLeary, DS ;
Cizadlo, T ;
Arndt, S ;
Rezai, K ;
Ponto, LLB ;
Watkins, GL ;
Hichwa, RD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (18) :9985-9990
[2]  
[Anonymous], 1965, 2 FACTOR INDEX SOCIA
[3]   MRI study of white matter diffusion anisotropy in schizophrenia [J].
Ardekani, BA ;
Nierenberg, J ;
Hoptman, MJ ;
Javitt, DC ;
Lim, KO .
NEUROREPORT, 2003, 14 (16) :2025-2029
[4]   Investigation of corpus callosum in schizophrenia with diffusion imaging [J].
Brambilla, P ;
Cerini, R ;
Gasparini, A ;
Versace, A ;
Andreone, N ;
Vittorini, E ;
Barbui, C ;
Pelizza, L ;
Nosè, M ;
Barlocco, L ;
Marrella, G ;
Gregis, M ;
Tournikioti, K ;
David, AS ;
Keshavan, MS ;
Tansella, M .
SCHIZOPHRENIA RESEARCH, 2005, 79 (2-3) :201-210
[5]   Diffusion tensor imaging in schizophrenia [J].
Buchsbaum, Monte S. ;
Friedman, Joseph ;
Buchsbaum, Bradley R. ;
Chu, King-Wai ;
Hazlett, Erin A. ;
Newmark, Randall ;
Schneiderman, Jason S. ;
Torosjan, Yuliya ;
Tang, Cheuk ;
Hof, Patrick R. ;
Stewart, Daniel ;
Davis, Kenneth L. ;
Gorman, Jack .
BIOLOGICAL PSYCHIATRY, 2006, 60 (11) :1181-1187
[6]   MRI white matter diffusion anisotropy and PET metabolic rate in schizophrenia [J].
Buchsbaum, MS ;
Tang, CY ;
Peled, S ;
Gudbjartsson, H ;
Lu, DF ;
Hazlett, EA ;
Downhill, J ;
Haznedar, M ;
Fallon, JH ;
Atlas, SW .
NEUROREPORT, 1998, 9 (03) :425-430
[7]   Structural disconnectivity in schizophrenia: a diffusion tensor magnetic resonance imaging study [J].
Burns, J ;
Job, D ;
Bastin, ME ;
Whalley, H ;
MacGillivray, T ;
Johnstone, EC ;
Lawrie, SM .
BRITISH JOURNAL OF PSYCHIATRY, 2003, 182 :439-443
[8]   Visual white matter integrity in schizophrenia [J].
Butler, Pamela D. ;
Hoptman, Matthew J. ;
Nierenberg, Jay ;
Foxe, John J. ;
Javitt, Daniel C. ;
Lim, Kelvin O. .
AMERICAN JOURNAL OF PSYCHIATRY, 2006, 163 (11) :2011-2013
[9]  
CHEUNG V, 2007, PSYCHOL MED, P1
[10]   TOPOGRAPHY OF THE UNCINATE FASCICLE AND ADJACENT TEMPORAL FIBER TRACTS [J].
EBELING, U ;
VONCRAMON, D .
ACTA NEUROCHIRURGICA, 1992, 115 (3-4) :143-148