Innovation - Anti-infectives - Predicting the evolution of antibiotic resistance genes

被引：76

作者：

Hall, BG ^{[1
]}

机构：

[1] Univ Rochester, Dept Biol, Rochester, NY 14627 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2004年 / 2卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrmicro888

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Antibiotic resistance is thought to evolve rapidly in response to antibiotic use. At present, we lack effective tools to assess how rapidly existing resistance genes are likely to evolve to yield resistance to newly introduced drugs. To address this problem, a method has been developed for in vitro evolution experiments to help predict how long it will take antibiotic resistance to arise - potentially allowing informed decisions about usage to be made.

引用

页码：430 / 435

页数：6

共 23 条

[1]

[Anonymous], 1998, ANTIMICROBIAL RESIST

[2]

Barlow M, 2003, GENETICS, V164, P23

[3]

Barlow M, 2003, GENETICS, V163, P1237

[4] Phylogenetic analysis shows that the OXA β-lactamase genes have been on plasmids for millions of years [J].