Antibiotic stress induces genetic transformability in the human pathogen Streptococcus pneumoniae

被引：335

作者：

Prudhomme, Marc ^{[1
]}

Attaiech, Laetitia ^{[1
]}

Sanchez, Guillaume ^{[1
]}

Martin, Bernard ^{[1
]}

Claverys, Jean-Pierre ^{[1
]}

机构：

[1] Univ Toulouse 3, CNRS, UMR 5100, Lab Microbiol & Genet Mol, F-31062 Toulouse 9, France

来源：

SCIENCE | 2006年 / 313卷 / 5783期

关键词：

D O I：

10.1126/science.1127912

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Natural transformation is a widespread mechanism for genetic exchange in bacteria. Aminoglycoside and fluoroquinolone antibiotics, as well as mitomycin C, a DNA-damaging agent, induced transformation in Streptococcus pneumoniae. This induction required an intact competence regulatory cascade. Furthermore, mitomycin C induction of recA was strictly dependent on the development of competence. In response to antibiotic stress, S. pneumoniae, which lacks an SOS-like system, exhibited genetic transformation. The design of antibiotherapy should take into consideration this potential of a major human pathogen to increase its rate of genetic exchange in response to antibiotics.

引用

页码：89 / 92

页数：4

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