Convenient indole synthesis from ethynylanilines with a polymer-supported fluoride

被引：25

作者：

Yasuhara, A ^{[1
]}

Suzuki, N ^{[1
]}

Yoshino, T ^{[1
]}

Takeda, Y ^{[1
]}

Sakamoto, T ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 37期

关键词：

D O I：

10.1016/S0040-4039(02)01439-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cyclization reaction of ethynylanilines having phenyl, alkyl, methoxy, cyano. chloro, mid ethoxycarbonyl groups with (polystyrylmethyl)trimethylammonium fluoride in dry MeCN under an argon atmosphere at 100degreesC proceeded in good yields to give the corresponding indoles without affecting these functional groups. Moreover, the polymer-Supported fluoride could be reused for the cyclization reaction when the deprotection reaction of the N-substituted indole with the fluoride ion 011 resin did not occur under the cyclization conditions. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：6579 / 6582

页数：4

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