Mapping the antigenic and genetic evolution of influenza virus

被引：1374

作者：

Smith, DJ

Lapedes, AS

de Jong, JC

Bestebroer, TM

Rimmelzwaan, GF

Osterhaus, ADME

Fouchier, RAM

机构：

[1] Univ Cambridge, Dept Zool, Cambridge CB2 3EJ, England

[2] Erasmus MC, Natl Influenza Ctr, NL-3015 GE Rotterdam, Netherlands

[3] Erasmus MC, Dept Virol, NL-3015 GE Rotterdam, Netherlands

[4] Los Alamos Natl Lab, Div Theoret, Los Alamos, NM 87545 USA

来源：

SCIENCE | 2004年 / 305卷 / 5682期

关键词：

D O I：

10.1126/science.1097211

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The antigenic evolution of influenza A (H3N2) virus was quantified and visualized from its introduction into humans in 1968 to 2003. Although there was remarkable correspondence between antigenic and genetic evolution, significant differences were observed: Antigenic evolution was more punctuated than genetic evolution, and genetic change sometimes had a disproportionately large antigenic effect. The method readily allows monitoring of antigenic differences among vaccine and circulating strains and thus estimation of the effects of vaccination. Further, this approach offers a route to predicting the relative success of emerging strains, which could be achieved by quantifying the combined effects of population level immune escape and viral fitness on strain evolution.

引用

页码：371 / 376

页数：6

共 34 条

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