Hemodialysis-induced cardiovascular disease

被引：196

作者：

Ahmadmehrabi, Shadi ^{[1
]}

Tang, W. H. Wilson ^{[2
,3
,4
]}

机构：

[1] Case Western Reserve Univ, Cleveland Clin Lerner Coll, Cleveland, OH 44106 USA

[2] Cleveland Clin, Dept Cardiovasc Med, Heart & Vasc Inst, Cleveland, OH 44106 USA

[3] Cleveland Clin, Ctr Clin Genom, Cleveland, OH 44106 USA

[4] Cleveland Clin, Dept Cellular & Mol Med, Lerner Res Inst, Cleveland, OH 44106 USA

来源：

SEMINARS IN DIALYSIS | 2018年 / 31卷 / 03期

基金：

美国国家卫生研究院;

关键词：

TRIMETHYLAMINE-N-OXIDE; CHRONIC KIDNEY-DISEASE; HIGH-DENSITY-LIPOPROTEIN; INTIMA-MEDIA THICKNESS; STAGE RENAL-DISEASE; ALL-CAUSE MORTALITY; LEFT-VENTRICULAR MASS; BOUND UREMIC TOXINS; DIALYSIS PATIENTS; NITRIC-OXIDE;

D O I：

10.1111/sdi.12694

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

100201 [内科学]; 100221 [泌尿外科学];

摘要：

More than half of all deaths among end stage renal disease (ESRD) patients are due to cardiovascular disease (CVD). Cardiovascular changes secondary to renal dysfunction, including fluid overload, uremic cardiomyopathy, secondary hyperparathyroidism, anemia, altered lipid metabolism, and accumulation of gut microbiota-derived uremic toxins like trimethylamine N-oxidase, contribute to the high risk for CVD in the ESRD population. In addition, conventional hemodialysis (HD) itself poses myocardial stress and injury on the already compromised cardiovascular system in uremic patients. This review will provide an overview of cardiovascular changes in chronic kidney disease and ESRD, a description of reported mechanisms for HD-induced myocardial injury, comparison of HD with other treatment modalities in the context of CVD, and possible management strategies.

引用

页码：258 / 267

页数：10

共 110 条

[1]

Electrocardiographic abnormalities in patients receiving hemodialysis [J].

Abe, S ;

Yoshizawa, M ;

Nakanishi, N ;

Yazawa, T ;

Yokota, K ;

Honda, M ;

Sloman, G .

AMERICAN HEART JOURNAL, 1996, 131 (06) :1137-1144

[2]

Hypertension in hemodialysis patients treated with atenolol or lisinopril: a randomized controlled trial [J].

Agarwal, Rajiv ;

Sinha, Arjun D. ;

Pappas, Maria K. ;

Abraham, Terri N. ;

Tegegne, Getachew G. .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2014, 29 (03) :672-681

[3]

How can we prevent intradialytic hypotension? [J].

Agarwal, Rajiv .

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 2012, 21 (06) :593-599

[4]

[Anonymous], 2016 ANN DAT REP EP

[5]

Hemodialysis-Induced Regional Left Ventricular Systolic Dysfunction: Prevalence, Patient and Dialysis Treatment-Related Factors, and Prognostic Significance [J].

Assa, Solmaz ;

Hummel, Yoran M. ;

Voors, Adriaan A. ;

Kuipers, Johanna ;

Westerhuis, Ralf ;

de Jong, Paul E. ;

Franssen, Casper F. M. .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2012, 7 (10) :1615-1623

[6]

2016 ESC/EAS Guidelines for the Management of Dyslipidaemias The Task Force for the Management of Dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS) Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR) [J].

Catapano, Alberico L. ;

Graham, Ian ;

De Backer, Guy ;

Wiklund, Olov ;

Chapman, M. John ;

Drexel, Heinz ;

Hoes, Arno W. ;

Jennings, Catriona S. ;

Landmesser, Ulf ;

Pedersen, Terje R. ;

Reiner, Zeljko ;

Riccardi, Gabriele ;

Taskinen, Marja-Riita ;

Tokgozoglu, Lale ;

Verschuren, W. M. Monique ;

Vlachopoulos, Charalambos ;

Wood, David A. ;

Luis Zamorano, Jose .

ATHEROSCLEROSIS, 2016, 253 :281-344

[7]

The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial [J].

Baigent, Colin ;

Landray, Martin J. ;

Reith, Christina ;

Emberson, Jonathan ;

Wheeler, David C. ;

Tomson, Charles ;

Wanner, Christoph ;

Krane, Vera ;

Cass, Alan ;

Craig, Jonathan ;

Neal, Bruce ;

Jiang, Lixin ;

Hooi, Lai Seong ;

Levin, Adeera ;

Agodoa, Lawrence ;

Gaziano, Mike ;

Kasiske, Bertram ;

Walker, Robert ;

Massy, Ziad A. ;

Feldt-Rasmussen, Bo ;

Krairittichai, Udom ;

Ophascharoensuk, Vuddidhej ;

Fellstrom, Bengt ;

Holdaas, Hallvard ;

Tesar, Vladimir ;

Wiecek, Andrzej ;

Grobbee, Diederick ;

de Zeeuw, Dick ;

Gronhagen-Riska, Carola ;

Dasgupta, Tanaji ;

Lewis, David ;

Herrington, William ;

Mafham, Marion ;

Majoni, William ;

Wallendszus, Karl ;

Grimm, Richard ;

Pedersen, Terje ;

Tobert, Jonathan ;

Armitage, Jane ;

Baxter, Alex ;

Bray, Christopher ;

Chen, Yiping ;

Chen, Zhengming ;

Hill, Michael ;

Knott, Carol ;

Parish, Sarah ;

Simpson, David ;

Sleight, Peter ;

Young, Alan ;

Collins, Rory .

LANCET, 2011, 377 (9784) :2181-2192

[8]

Accumulation of trimethylamine and trimethylamine-N-oxide in end-stage renal disease patients undergoing haemodialysis [J].

Bain, MA ;

Faull, R ;

Fornasini, G ;

Milne, RW ;

Evans, AM .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2006, 21 (05) :1300-1304

[9]

Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation [J].

Bennett, Brian J. ;

Vallim, Thomas Q. de Aguiar ;

Wang, Zeneng ;

Shih, Diana M. ;

Meng, Yonghong ;

Gregory, Jill ;

Allayee, Hooman ;

Lee, Richard ;

Graham, Mark ;

Crooke, Rosanne ;

Edwards, Peter A. ;

Hazen, Stanley L. ;

Lusis, Aldons J. .

CELL METABOLISM, 2013, 17 (01) :49-60

[10]

Proteomics characterization of protein adsorption onto hemodialysis membranes [J].

Bonomini, Mario ;

Pavone, Barbara ;

Sirolli, Vittorio ;

Del Buono, Francesca ;

Di Cesare, Moreno ;

Del Boccio, Piero ;

Amoroso, Luigi ;

Di Ilio, Carmine ;

Sacchetta, Paolo ;

Federici, Giorgio ;

Urbani, Andrea .

JOURNAL OF PROTEOME RESEARCH, 2006, 5 (10) :2666-2674

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