Chemotherapy-related secondary acute myeloid leukemia in patients diagnosed with osteosarcoma

被引：11

作者：

Escudero, MC ^{[1
]}

Lassaletta, A ^{[1
]}

Sevilla, J ^{[1
]}

Fernandez-Plaza, S ^{[1
]}

Pérez, A ^{[1
]}

Diaz, MA ^{[1
]}

Madero, L ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Serv Oncol, Hosp Nino Jesus, Dept Pediat Oncol, Madrid 28009, Spain

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2004年 / 26卷 / 07期

关键词：

osteosarcoma; alkylating agents; topoisomerase II inhibitors; platinum; secondary leukemia;

D O I：

10.1097/00043426-200407000-00012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Secondary acute leukemia (SAL) after treatment of osteosarcoma has been seldom reported in children. Two main mechanisms that can induce SAL have been described. The authors describe two patients who developed SAL after treatment with multiagent therapy. The first patient developed a secondary acute leukemia after treatment with alkylating agents and platinum compounds. The second patient had the clinical and molecular features of a secondary acute leukemia due to topoisomerase 11 inhibitors. The authors also discuss the data regarding cisplatin-associated SAL. Different molecular and pathogenic agents may be implicated in the development of second malignant neoplasms in long-term survivors of osteosarcomas.

引用

页码：454 / 456

页数：3

共 15 条

[1] Second malignant neoplasms in long-term survivors of osteosarcoma - Memorial sloan-kettering cancer center experience [J].

Aung, L ;

Gorlick, RG ;

Shi, W ;

Thaler, H ;

Shorter, NA ;

Healey, JH ;

Huvos, AG ;

Meyers, PA .

CANCER, 2002, 95 (08) :1728-1734

[2] Long-term complications of chemotherapy for germ cell tumours [J].

Chaudhary, UB ;

Haldas, JR .

DRUGS, 2003, 63 (15) :1565-1577

[3] TRANSLOCATION T(9-11)(P21-Q23) WITH ACUTE MYELOMONOCYTIC LEUKEMIA AFTER CHEMOTHERAPY FOR OSTEOSARCOMA - GOOD RESPONSE TO ANTILEUKEMIC DRUGS [J].

FENAUX, P ;

JOUET, JP ;

BAUTERS, F ;

LAI, JL ;

LEPELLEY, P .

JOURNAL OF CLINICAL ONCOLOGY, 1987, 5 (08) :1304-1305

[4]

Kawai A, 2001, CLIN ORTHOP RELAT R, P239

[5]

Panizo C, 1998, MED PEDIATR ONCOL, V30, P165, DOI 10.1002/(SICI)1096-911X(199803)30:3<165::AID-MPO7>3.3.CO

[6]

2-A

[7] Therapy-related acute myeloid leukemia and myelodysplasia after high-dose chemotherapy and autologous stem cell transplantation [J].

Pedersen-Bjergaard, J ;

Andersen, MK ;

Christiansen, DH .

BLOOD, 2000, 95 (11) :3273-3279

[8]

Pegram AA, 2001, ANN PHARMACOTHER, V35, P935

[9] Platinum agents and secondary myeloid leukaemia: Two cases treated only with platinum-based drugs [J].

Philpott, NJ ;

Elebute, MO ;

Powles, R ;

Treleaven, JG ;

Gore, M ;

Dainton, MG ;

Min, T ;

Swansbury, GJ ;

Catovsky, D .

BRITISH JOURNAL OF HAEMATOLOGY, 1996, 93 (04) :884-887

[10] MYELOID NEOPLASIA IN CHILDREN TREATED FOR SOLID TUMORS [J].

PUI, CH ;

HANCOCK, ML ;

RAIMONDI, SC ;

HEAD, DR ;

THOMPSON, E ;

WILIMAS, J ;

KUN, LE ;

BOWMAN, LC ;

CRIST, WM ;

PRATT, CB .

LANCET, 1990, 336 (8712) :417-421

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