Impaired antiviral response and alpha/beta interferon induction in mice lacking beta interferon

被引：141

作者：

Deonarain, R

Alcamí, A

Alexiou, M

Dallman, MJ

Gewert, DR

Porter, ACG

机构：

[1] Hammersmith Hosp, Imperial Coll, MRC,Clin Sci Ctr, Sch Med,Gene Targeting Grp, London W12 0NN, England

[2] Univ Cambridge, Dept Pathol, Div Virol, Cambridge CB2 1QP, England

[3] Univ London Imperial Coll Sci Technol & Med, Dept Biol, London SW7 2AZ, England

[4] QT Genet Ltd, Cambridge CB4 3GA, England

来源：

JOURNAL OF VIROLOGY | 2000年 / 74卷 / 07期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/JVI.74.7.3404-3409.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have generated mice lacking the gene for beta interferon and report that they are highly susceptible to vaccinia virus infection. Furthermore, in cultured embryo fibroblasts, viral induction of alpha interferon and of 2-5A synthetase genes is impaired. We also show that beta interferon does not prime its own expression.

引用

页码：3404 / 3409

页数：6

共 47 条

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