Cerebral amyloid angiopathy severity is linked to dilation of juxtacortical perivascular spaces

被引：95

作者：

van Veluw, Susanne J. ^{[1
,2
]}

Biessels, Geert Jan ^{[1
]}

Bouvy, Willem H. ^{[1
]}

Spliet, Wim G. M. ^{[3
]}

Zwanenburg, Jaco J. M. ^{[4
]}

Luijten, Peter R. ^{[4
]}

Macklin, Eric A. ^{[5
,6
]}

Rozemuller, Annemieke J. M. ^{[3
]}

Gurol, M. Edip ^{[2
]}

Greenberg, Steven M. ^{[2
]}

Viswanathan, Anand ^{[2
]}

Martinez-Ramirez, Sergi ^{[2
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Neurol, Brain Ctr Rudolf Magnus, NL-3508 GA Utrecht, Netherlands

[2] MGH, JPK Stroke Res Ctr, Dept Neurol, Boston, MA USA

[3] Univ Med Ctr Utrecht, Dept Pathol, NL-3508 GA Utrecht, Netherlands

[4] Univ Med Ctr Utrecht, Dept Radiol, NL-3508 GA Utrecht, Netherlands

[5] MGH, Biostat Ctr, Boston, MA USA

[6] Harvard Univ, Sch Med, Boston, MA USA

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2016年 / 36卷 / 03期

基金：

欧洲研究理事会;

关键词：

7 T magnetic resonance imaging; amyloid angiopathy; histology; microbleeds; perivascular spaces; ALZHEIMERS-DISEASE;

D O I：

10.1177/0271678X15620434

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Perivascular spaces are an emerging marker of small vessel disease. Perivascular spaces in the centrum semiovale have been associated with cerebral amyloid angiopathy. However, a direct topographical relationship between dilated perivascular spaces and cerebral amyloid angiopathy severity has not been established. We examined this association using post-mortem magnetic resonance imaging in five cases with evidence of cerebral amyloid angiopathy pathology. Juxtacortical perivascular spaces dilation was evaluated on T2 images and related to cerebral amyloid angiopathy severity in overlying cortical areas on 34 tissue sections stained for Amyloid beta. Degree of perivascular spaces dilation was significantly associated with cerebral amyloid angiopathy severity (odds ratio = 3.3, 95% confidence interval 1.3-7.9, p = 0.011). Thus, dilated juxtacortical perivascular spaces are a promising neuroimaging marker of cerebral amyloid angiopathy severity.

引用

页码：576 / 580

页数：5

共 9 条

[1] Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology [J].

Carare, R. O. ;

Bernardes-Silva, M. ;

Newman, T. A. ;

Page, A. M. ;

Nicoll, J. A. R. ;

Perry, V. H. ;

Weller, R. O. .

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2008, 34 (02) :131-144

[2] White Matter Perivascular Spaces on Magnetic Resonance Imaging Marker of Cerebrovascular Amyloid Burden? [J].

Charidimou, Andreas ;

Hong, Young T. ;

Jaeger, Hans R. ;

Fox, Zoe ;

Aigbirhio, Franklin I. ;

Fryer, Tim D. ;

Menon, David K. ;

Warburton, Elizabeth A. ;

Werring, David J. ;

Baron, Jean-Claude .

STROKE, 2015, 46 (06) :1707-1709

[3]

Charidimou A, 2015, NEUROLOGY, V84, P1206, DOI [10.1212/WNL.0000000000003115, 10.1212/WNL.0000000000001398]

[4]

Love Seth, 2014, Am J Neurodegener Dis, V3, P19

[5] Topography of dilated perivascular spaces in subjects from a memory clinic cohort [J].

Martinez-Ramirez, Sergi ;

Pontes-Neto, Octavio Marques ;

Dumas, Andrew P. ;

Auriel, Eitan ;

Halpin, Amy ;

Quimby, Megan ;

Gurol, Mahmut Edip ;

Greenberg, Steven M. ;

Viswanathan, Anand .

NEUROLOGY, 2013, 80 (17) :1551-1556

[6] Cortical and leptomeningeal cerebrovascular amyloid and white matter pathology in Alzheimer's disease [J].

Roher, AE ;

Kuo, YM ;

Esh, C ;

Knebel, C ;

Weiss, N ;

Kalback, W ;

Luehrs, DC ;

Childress, JL ;

Beach, TG ;

Weller, RO ;

Kokjohn, TA .

MOLECULAR MEDICINE, 2003, 9 (3-4) :112-122

[7] CEREBRAL AMYLOID ANGIOPATHY - A CRITICAL-REVIEW [J].

VINTERS, HV .

STROKE, 1987, 18 (02) :311-324

[8] Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration [J].

Wardlaw, Joanna M. ;

Smith, Eric E. ;

Biessels, Geert J. ;

Cordonnier, Charlotte ;

Fazekas, Franz ;

Frayne, Richard ;

Lindley, Richard I. ;

O'Brien, John T. ;

Barkhof, Frederik ;

Benavente, Oscar R. ;

Black, Sandra E. ;

Brayne, Carol ;

Breteler, Monique ;

Chabriat, Hugues ;

DeCarli, Charles ;

de Leeuw, Frank-Erik ;

Doubal, Fergus ;

Duering, Marco ;

Fox, Nick C. ;

Greenberg, Steven ;

Hachinski, Vladimir ;

Kilimann, Ingo ;

Mok, Vincent ;

van Oostenbrugge, Robert ;

Pantoni, Leonardo ;

Speck, Oliver ;

Stephan, Blossom C. M. ;

Teipel, Stefan ;

Viswanathan, Anand ;

Werring, David ;

Chen, Christopher ;

Smith, Colin ;

van Buchem, Mark ;

Norrving, Bo ;

Gorelick, Philip B. ;

Dichgans, Martin .

LANCET NEUROLOGY, 2013, 12 (08) :822-838

[9] Microvasculature changes and cerebral amyloid angiopathy in Alzheimer's disease and their potential impact on therapy [J].

Weller, Roy O. ;

Boche, Delphine ;

Nicoll, James A. R. .

ACTA NEUROPATHOLOGICA, 2009, 118 (01) :87-102

← 1 →