Lymphoid Lineage Fate Decision of Hematopoietic Stem Cells

被引：5

作者：

Akashi, Koichi ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA

[2] Kyushu Univ, Fac Med, Dept Med & Biosyst Sci, Fukuoka 812, Japan

来源：

HEMATOPOIETIC STEM CELLS VII | 2009年 / 1176卷

关键词：

hematopoietic stem cells (HSCs); hematopoiesis; myelo-lymphoid precursors; BONE-MARROW; PROGENITOR CELLS; FLT3; LIGAND; RAG1; LOCUS; PU.1; GATA-1; TRANSCRIPTION; COMMITMENT; EXPRESSION; DIFFERENTIATION;

D O I：

10.1111/j.1749-6632.2009.04570.x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

To understand the mechanism in lymphoid development, it is critical to identify developmental intermediates downstream of hematopoietic stem cells, including cells responsible for seeding the thymus. Although early studies showed that hematopoietic stem cells choose either the myeloid-erythroid or the lymphoid pathway, recent data suggest that myelo-lymphoid precursors lacking erythroid potential exist in early hematopoiesis before cells are fully committed to the lymphoid lineage. We here summarize the phenotype and functional properties of such progenitors and the current developmental map for the lymphoid lineage.

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页码：18 / 25

页数：8

相关论文

共 43 条

[1] Upregulation of flt3 expression within the bone marrow Lin-Sca1+c-kit+ stem cell compartment is accompanied by loss of self-renewal capacity [J].

Adolfsson, J ;

Borge, OJ ;

Bryder, D ;

Theilgaard-Mönch, K ;

Åstrand-Grundström, I ;

Sitnicka, E ;

Sasaki, Y ;

Jacobsen, SEW .

IMMUNITY, 2001, 15 (04) :659-669

[2] Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential:: A revised road map for adult blood lineage commitment [J].

Adolfsson, J ;

Månsson, R ;

Buza-Vidas, N ;

Hultquist, A ;

Liuba, K ;

Jensen, CT ;

Bryder, D ;

Yang, LP ;

Borge, OJ ;

Thoren, LAM ;

Anderson, K ;

Sitnicka, E ;

Sasaki, Y ;

Sigvardsson, M ;

Jacobsen, SEW .

CELL, 2005, 121 (02) :295-306

[3] A clonogenic common myeloid progenitor that gives rise to all myeloid lineages [J].

Akashi, K ;

Traver, D ;

Miyamoto, T ;

Weissman, IL .

NATURE, 2000, 404 (6774) :193-197

[4] The complex cartography of stem cell commitment [J].

Akashi, K ;

Traver, D ;

Zon, LI .

CELL, 2005, 121 (02) :160-162

[5] Thymopoiesis independent of common lymphoid progenitors [J].

Allman, D ;

Sambandam, A ;

Kim, S ;

Miller, JP ;

Pagan, A ;

Well, D ;

Meraz, A ;

Bhandoola, A .

NATURE IMMUNOLOGY, 2003, 4 (02) :168-174

[6] Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages [J].

Arinobu, Yojiro ;

Mizuno, Shin-ichi ;

Chong, Yong ;

Shigematsu, Hirokazu ;

Lino, Tadafumi ;

Iwasaki, Hiromi ;

Graf, Thomas ;

Mayfield, Robin ;

Chan, Susan ;

Kastner, Philippe ;

Akashi, Koichi .

CELL STEM CELL, 2007, 1 (04) :416-427

[7] Visualizing PU.1 activity during hematopoiesis [J].

Back, J ;

Allman, D ;

Chan, S ;

Kastner, P .

EXPERIMENTAL HEMATOLOGY, 2005, 33 (04) :395-402

[8] From stem cell to T cell: one route or many? [J].

Bhandoola, A ;

Sambandam, A .

NATURE REVIEWS IMMUNOLOGY, 2006, 6 (02) :117-126

[9] Flk-2 is a marker in hematopoietic stem cell differentiation: A simple method to isolate long-term stem cells [J].

Christensen, JL ;

Weissman, IL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (25) :14541-14546

[10] PU.1 regulates expression of the interleukin-7 receptor in lymphoid progenitors [J].

DeKoter, RP ;

Lee, HJ ;

Singh, H .

IMMUNITY, 2002, 16 (02) :297-309

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