A small number of open Ca2+ channels trigger transmitter release at a central GABAergic synapse

被引：90

作者：

Bucurenciu, Iancu ^{[1
]}

Bischofberger, Josef ^{[1
,2
]}

Jonas, Peter ^{[1
,3
]}

机构：

[1] Univ Freiburg, Inst Physiol 1, Freiburg, Germany

[2] Univ Basel, Inst Physiol, Basel, Switzerland

[3] Freiburg Inst Adv Studies, Freiburg, Germany

来源：

NATURE NEUROSCIENCE | 2010年 / 13卷 / 01期

关键词：

CALCIUM-CHANNEL; N-TYPE; VESICLE; CALYX;

D O I：

10.1038/nn.2461

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To determine the number of open Ca2+ channels necessary for transmitter release at the inhibitory basket cell-granule cell synapse in rat hippocampus, we combined presynaptic Ca2+ imaging, recording of postsynaptic currents and modeling. We found that that the opening of three or fewer Ca2+ channels triggered transmitter release. Furthermore, a small number of Ca2+ channels were able to evoke release with high temporal precision, despite stochastic Ca2+ channel opening.

引用

收藏

页码：19 / 21

页数：3

相关论文

共 15 条

[1] THE CALCIUM SIGNAL FOR TRANSMITTER SECRETION FROM PRESYNAPTIC NERVE-TERMINALS [J].

AUGUSTINE, GJ ;

ADLER, EM ;

CHARLTON, MP .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES, 1991, 635 :365-381

[2] Modeling study of the effects of overlapping Ca2+ microdomains on neurotransmitter release [J].

Bertram, R ;

Smith, GD ;

Sherman, A .

BIOPHYSICAL JOURNAL, 1999, 76 (02) :735-750

[3] Calcium influx and transmitter release in a fast CNS synapse [J].

Borst, JGG ;

Sakmann, B .

NATURE, 1996, 383 (6599) :431-434

[4] Few CaV1.3 channels regulate the exocytosis of a synaptic vesicle at the hair cell ribbon synapse [J].

Brandt, A ;

Khimich, D ;

Moser, T .

JOURNAL OF NEUROSCIENCE, 2005, 25 (50) :11577-11585

[5] Nanodomain coupling between Ca2+ channels and Ca2+ sensors promotes fast and efficient transmitter release at a cortical GABAergic synapse [J].

Bucurenciu, Iancu ;

Kulik, Akos ;

Schwaller, Beat ;

Frotscher, Michael ;

Jonas, Peter .

NEURON, 2008, 57 (04) :536-545

[6] Developmental transformation of the release modality at the calyx of held synapse [J].

Fedchyshyn, MJ ;

Wang, LY .

JOURNAL OF NEUROSCIENCE, 2005, 25 (16) :4131-4140

[7] Differential gating and recruitment of P/Q-, N-, and R-Type Ca2+ channels in hippocampal mossy fiber boutons [J].

Li, Liyi ;

Bischofberger, Josef ;

Jonas, Peter .

JOURNAL OF NEUROSCIENCE, 2007, 27 (49) :13420-13429

[8] CALCIUM CONTROL OF TRANSMITTER RELEASE AT A CEREBELLAR SYNAPSE [J].

MINTZ, IM ;

SABATINI, BL ;

REGEHR, WG .

NEURON, 1995, 15 (03) :675-688

[9] Usefulness and limitations of linear approximations to the understanding of Ca++ signals [J].

Neher, E .

CELL CALCIUM, 1998, 24 (5-6) :345-357

[10] Ca2+ from one or two channels controls fusion of a single vesicle at the frog neuromuscular junction [J].

Shahrezaei, Vahid ;

Cao, Alex ;

Delaney, Kerry R. .

JOURNAL OF NEUROSCIENCE, 2006, 26 (51) :13240-13249