Why are zinc phosphatases multinuclear?

被引：7

作者：

Kimura, E

Koike, T

Aoki, S

机构：

[1] Department of Medicinal Chemistry, School of Medicine, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima

来源：

JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN | 1997年 / 55卷 / 11期

关键词：

D O I：

10.5059/yukigoseikyokaishi.55.1052

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Macrocyclic polyamines are a new class of multifunctional molecules (e.g., complexing agents for cations, anions and neutral molecules). Recently, a new insight into zinc enzyme chemistry has been achieved by studies of multinuclear zinc(II) complexes with macrocyclic polyamines. These complexes serve as both the structural and functional models for the active centers of multinuclear zinc(II)-containing phosphatases (e.g., alkaline phosphatase, and protein serine/threonine phosphatase-1) and have given answers to some basic questions that surround the intrinsic properties of metal ions in those enzymes.

引用

页码：1052 / 1061

页数：10

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