Analysis of Protein Conformation and Dynamics by Hydrogen/Deuterium Exchange MS

被引：287

作者：

Engen, John R. ^{[1
]}

机构：

[1] Northeastern Univ, Boston, MA 02115 USA

来源：

ANALYTICAL CHEMISTRY | 2009年 / 81卷 / 19期

关键词：

AMIDE HYDROGEN-EXCHANGE; MASS-SPECTROMETRY; LIQUID-CHROMATOGRAPHY; RESOLUTION; SEQUENCE; THERAPEUTICS; SEPARATION; ANTIBODY; UPLC;

D O I：

10.1021/ac901154s

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Understanding as much as possible about proteins in the shortest amount of time has long been a goal of hydrogen exchange (HX) MS. Recent technological advances have led to improvements in the technique, but has this goal yet been achieved? (To listen to a podcast about this Feature, please go to the Analytical Chemistry Web site at pubs.acs.org/journal/ancham.)

引用

收藏

页码：7870 / 7875

页数：6

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