Chemical Constituents of the Bulbs of Habranthus brachyandrus and Their Cytotoxic Activities

被引：35

作者：

Jitsuno, Maki ^{[1
]}

Yokosuka, Akihito ^{[1
]}

Sakagami, Hiroshi ^{[2
]}

Mimaki, Yoshihiro ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Lab Med Pharmacognosy, Sch Pharm, Tokyo 1920392, Japan

[2] Meikai Univ, Sch Dent, Dept Dent Pharmacol, Saitama 3500283, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2009年 / 57卷 / 10期

关键词：

Habranthus brachyandrus; Amaryllidaceae; flavan derivative; hydroxybutyric acid glucoside; HL-60; cell; HSC-2; AMARYLLIDACEAE ALKALOIDS; ABSOLUTE-CONFIGURATION; PHENOLIC-COMPOUNDS; DRAGONS BLOOD;

D O I：

10.1248/cpb.57.1153

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

The bulbs of Habranthus brachyandrus (Amaryllidaceae) have been extensively analyzed for their chemical constituents, resulting in the isolation of eight flavan derivatives (1-8), four of which are new naturally occurring compounds; a new hydroxybutyric acid glucoside (9); three known phenolic compounds (10-12); and six known alkaloids (13-18). The structures of the new compounds were determined on the basis of spectroscopic analysis, including two-dimensional (2D) NMR data, and chemical evidence. The isolated compounds and a few derivatives were evaluated for their cytotoxic activities against HL-60 human promyelocytic leukemia cells and HSC-2 human oral squamous cell carcinoma cells.

引用

页码：1153 / 1157

页数：5

共 17 条

[1]

CONSTITUENTS OF TROPICAL MEDICINAL PLANTS .31. FLAVONOID AND OTHER CONSTITUENTS OF BAUHINIA-MANCA [J].