The bacterial transcription repair coupling factor

被引：29

作者：

Deaconescu, Alexandra M. ^{[1
]}

Savery, Nigel ^{[1
]}

Darst, Seth A. ^{[1
]}

机构：

[1] Univ Bristol, Sch Med Sci, Dept Biochem, Bristol BS8 1TD, Avon, England

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2007年 / 17卷 / 01期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/j.sbi.2007.01.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The widely conserved bacterial transcription repair coupling factor (TRCF) is a large, multidomain, superfamily 2 ATPase. It couples nucleotide excision repair with transcription by dislodging inactive RNA polymerase molecules stalled at template DNA lesions and increasing the rate at which the Uvr(A)BC excinuclease acts at these sites. The recent elucidation of X-ray crystal structures of Escherichia coli TRCF revealed its architectural details, and will enable the design of more incisive experiments addressing how TRCF translocates on double-stranded DNA, destabilizes the RNA polymerase ternary elongation complex and recruits the Uvr(A)BC system.

引用

页码：96 / 102

页数：7

共 34 条

[1] Structural basis for transcription-coupled repair: The N terminus of Mfd resembles UvrB with degenerate ATPase motifs [J].

Assenmacher, N ;

Wenig, K ;

Lammens, A ;

Hopfner, KP .

JOURNAL OF MOLECULAR BIOLOGY, 2006, 355 (04) :675-683

[2] DNA-REPAIR IN AN ACTIVE GENE - REMOVAL OF PYRIMIDINE DIMERS FROM THE DHFR GENE OF CHO CELLS IS MUCH MORE EFFICIENT THAN IN THE GENOME OVERALL [J].

BOHR, VA ;

SMITH, CA ;

OKUMOTO, DS ;

HANAWALT, PC .

CELL, 1985, 40 (02) :359-369

[3] Interaction network containing conserved and essential protein complexes in Escherichia coli [J].

Butland, G ;

Peregrín-Alvarez, JM ;

Li, J ;

Yang, WH ;

Yang, XC ;

Canadien, V ;

Starostine, A ;

Richards, D ;

Beattie, B ;

Krogan, N ;

Davey, M ;

Parkinson, J ;

Greenblatt, J ;

Emili, A .

NATURE, 2005, 433 (7025) :531-537

[4] Helicase structure and mechanism [J].

Caruthers, JM ;

McKay, DB .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 2002, 12 (01) :123-133

[5] A DNA translocation motif in the bacterial transcription-repair coupling factor, Mfd [J].

Chambers, AL ;

Smith, AJ ;

Savery, NJ .

NUCLEIC ACIDS RESEARCH, 2003, 31 (22) :6409-6418

[6]

Deaconescu AM, 2006, CELL, V124, P507, DOI 10.1016/j.cell.2005.11.045

[7] Crystallization and preliminary structure determination of Escherichia coli Mfd, the transcription-repair coupling factor [J].

Deaconescu, AM ;

Darst, SA .

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2005, 61 :1062-1064

[8] X-ray structures of the Sulfolobus solfataricus SWI2/SNF2 ATPase core and its complex with DNA [J].

Dürr, H ;

Körner, C ;

Müller, M ;

Hickmann, V ;

Hopfner, KP .

CELL, 2005, 121 (03) :363-373

[9] RNA polymerase as a molecular motor [J].

Gelles, J ;

Landick, R .

CELL, 1998, 93 (01) :13-16

[10] HELICASES - AMINO-ACID-SEQUENCE COMPARISONS AND STRUCTURE-FUNCTION-RELATIONSHIPS [J].

GORBALENYA, AE ;

KOONIN, EV .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1993, 3 (03) :419-429

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