Bacterial cellulose membranes as transdermal delivery systems for diclofenac: In vitro dissolution and permeation studies

被引：113

作者：

Silva, Nuno H. C. S. ^{[1
]}

Rodrigues, Artur Filipe ^{[1
]}

Almeida, Isabel F. ^{[2
]}

Costa, Paulo C. ^{[2
]}

Rosado, Catarina ^{[3
]}

Pascoal Neto, Carlos ^{[1
]}

Silvestre, Armando J. D. ^{[1
]}

Freire, Carmen S. R. ^{[1
]}

机构：

[1] Univ Aveiro, Dept Chem, CICECO, P-3810193 Aveiro, Portugal

[2] Univ Porto, Fac Pharm, Dept Drug Sci, Lab Pharmaceut Technol, P-4100 Oporto, Portugal

[3] Univ Lusofona, UDE Expt Dermatol Unit, CBIOS, P-1749024 Lisbon, Portugal

来源：

CARBOHYDRATE POLYMERS | 2014年 / 106卷

关键词：

Bacterial cellulose membranes; Diclofenac sodium; Transdermal delivery; In vitro permeation; Franz cells; Human epidermal membranes; BIOCELLULOSE MEMBRANES; RELEASE; SODIUM; OSTEOARTHRITIS; NANOCELLULOSE;

D O I：

10.1016/j.carbpol.2014.02.014

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

Bacterial cellulose (BC) membranes were explored as novel nanostructured transdermal delivery systems for diclofenac sodium salt (a typical non-steroidal anti-inflammatory drug). Diclofenac sodium salt loaded BC membranes were prepared through a simple methodology, using glycerol as plasticizer, and characterized in terms of structure, morphology and swelling behavior. The membranes were very homogeneous, quite flexible and presented a considerably higher swelling behavior when compared with pure BC. In vitro diffusion studies with Franz cells, were conducted using human epidermal membranes, and showed that the incorporation of diclofenac in BC membranes provided similar permeation rates to those obtained with commercial patches and substantially lower than those observed with a commercial gel. This release profile together with the ease of application and the simple preparation and assembly of the drug-loaded membranes clearly indicates the enormous potentialities of using BC membranes for transdermal administration of diclofenac. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：264 / 269

页数：6

共 29 条

[1]

Almeida I. F., 2013, EUROPEAN J IN PRESS

[2]

Design, development, physicochemical, and in vitro and in vivo evaluation of transdermal patches containing diclofenac diethylammonium salt [J].