Analysis of cytokine dynamics in corneal allograft rejection

被引：15

作者：

Chan, CCW

Stark, J

George, AJT

机构：

[1] UCL, Ctr Nonlinear Dynam & Applicat, London WC1E 6BT, England

[2] Imperial Coll, Sch Med, Hammersmith Hosp, Dept Immunol,Div Med, London W12 0NN, England

来源：

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 1999年 / 266卷 / 1434期

关键词：

tumour necrosis factor-alpha; corneal transplantation; oscillations; nonlinear dynamics; mathematical model; cytokine network;

D O I：

10.1098/rspb.1999.0911

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Motivated by the discovery of oscillations in tumour necrosis factor-alpha (TNF-alpha) concentration in the aqueous humour of rabbits undergoing corneal allograft rejection, a simple mathematical model is developed for the regulation of TNF-alpha, which incorporates both negative feedback and amplification pathways. Mathematical analysis reveals a surprisingly rich behavioural repertoire for this simple cytokine pathway, including excitability, threshold behaviour, hysteresis, oscillations and bistability. This suggests new possibilities for experimental demonstration, and reveals the potential contributions of nonlinear dynamics to understanding cytokine regulation.

引用

页码：2217 / 2223

页数：7

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