Correlation of cerebral blood flow and treatment effects of repetitive transcranial magnetic stimulation in depressed patients

被引:119
作者
Mottaghy, FM
Keller, CE
Gangitano, M
Ly, J
Thall, M
Parker, JA
Pascual-Leone, A
机构
[1] Beth Israel Deaconess Med Ctr, Dept Neurol, Lab Magnet Brain Stimulat, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Boston, MA 02215 USA
[3] Res Ctr Julich, Dept Nucl Med KME, D-52426 Julich, Germany
[4] Beth Israel Deaconess Med Ctr, Dept Radiol, Div Nucl Med, Boston, MA 02215 USA
关键词
depression; transcranial magnetic stimulation; single photon emission tomography;
D O I
10.1016/S0925-4927(02)00032-X
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The aims of this study were to: (1) assess the effects of repetitive transcranial magnetic stimulation (rTMS) on brain activity in depressed patients as measured by single photon emission tomography (SPECT); (2) evaluate the predictive value of brain SPECT on the antidepressant efficacy of rTMS. Patients (n = 17) received 1600 rTMS stimuli at a rate of 10 Hz, 5 days per week for 2 weeks to the left dorsolateral prefrontal cortex. Whole brain SPECT data were acquired using Tc99m-Bicisate. Regional cerebral blood flow (rCBF) was correlated with the % change in the 28-item Hamilton Depression Rating Scale Score (Delta-HDRS) and a semiquantitative region of interest (ROI) analysis was conducted. Prior to rTMS there was a significant left-right asymmetry favoring the right, whereas 2 weeks after the rTMS treatment this asymmetry was reversed. The rCBF in limbic structures was negatively correlated with the outcome and rCBF in several neocortical areas was positively correlated. Brain SPECT can provide information about mechanisms of action of rTMS and may have predictive value for the antidepressant efficacy of rTMS. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:1 / 14
页数:14
相关论文
共 58 条
[1]  
[Anonymous], 1994, Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV), V4th
[2]   Connections underlying the synthesis of cognition, memory, and emotion in primate prefrontal cortices [J].
Barbas, H .
BRAIN RESEARCH BULLETIN, 2000, 52 (05) :319-330
[3]  
BAXTER LR, 1989, ARCH GEN PSYCHIAT, V46, P243
[4]   A combined TMS/fMRI study of intensity-dependent TMS over motor cortex [J].
Bohning, DE ;
Shastri, A ;
McConnell, KA ;
Nahas, Z ;
Lorberbaum, JP ;
Roberts, DR ;
Teneback, C ;
Vincent, DJ ;
George, MS .
BIOLOGICAL PSYCHIATRY, 1999, 45 (04) :385-394
[5]  
Bohning DE, 2000, J MAGN RESON IMAGING, V11, P569, DOI 10.1002/1522-2586(200006)11:6<569::AID-JMRI1>3.0.CO
[6]  
2-3
[7]   Cognitive and emotional influences in anterior cingulate cortex [J].
Bush, G ;
Luu, P ;
Posner, MI .
TRENDS IN COGNITIVE SCIENCES, 2000, 4 (06) :215-222
[8]   SPECT mapping of cerebral activity changes induced by repetitive transcranial magnetic stimulation in depressed patients.: A pilot study [J].
Catafau, AM ;
Perez, V ;
Gironell, A ;
Martin, JC ;
Kulisevsky, J ;
Estorch, M ;
Carrió, I ;
Alvarez, E .
PSYCHIATRY RESEARCH-NEUROIMAGING, 2001, 106 (03) :151-160
[9]   Impaired inhibition in writer's cramp during voluntary muscle activation [J].
Chen, R ;
Wassermann, EM ;
Canos, M ;
Hallett, M .
NEUROLOGY, 1997, 49 (04) :1054-1059
[10]   Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation [J].
Chen, R ;
Classen, J ;
Gerloff, C ;
Celnik, P ;
Wassermann, EM ;
Hallett, M ;
Cohen, LG .
NEUROLOGY, 1997, 48 (05) :1398-1403