Cardiomyopathy in Duchenne muscular dystrophy: pathogenesis and therapeutics

被引：90

作者：

Fayssoil, Abdallah ^{[1
]}

Nardi, Olivier ^{[2
]}

Orlikowski, David ^{[2
]}

Annane, Djillali ^{[2
]}

机构：

[1] Univ Med & Dent New Jersey, Camden, NJ USA

[2] Hop Raymond Poincare, Intens Care Unit, AP HP, Garches, France

来源：

HEART FAILURE REVIEWS | 2010年 / 15卷 / 01期

关键词：

Duchenne; Dystrophin; Heart failure; ACE inhibitors; Beta-blockers; Experimental therapies; CHRONIC HEART-FAILURE; SKELETAL-MUSCLE; MDX MICE; DILATED CARDIOMYOPATHY; INTRAARTERIAL DELIVERY; MOLECULAR-MECHANISMS; CELL THERAPY; STEM-CELLS; EXPRESSION; MOUSE;

D O I：

10.1007/s10741-009-9156-8

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder caused by the absence of dystrophin, a sarcolemmal protein which links the cytoskeleton to the extracellular matrix by interacting with a large number of proteins. Heart failure is a classic complication of this disease. The authors review the pathogenesis and therapeutics of cardiac involvement in DMD.

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页码：103 / 107

页数：5

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