On the role of cell surface carbohydrates and their binding proteins (lectins) in tumor metastasis

被引:238
作者
Gorelik, E
Galili, U
Raz, A
机构
[1] Univ Pittsburgh, Inst Canc, BST, Pittsburgh, PA 15213 USA
[2] Dept Pathol, Pittsburgh, PA USA
[3] Rush Univ, Dept Cardiothorac Surg, Chicago, IL 60612 USA
[4] Wayne State Univ, Karmanos Canc Inst, Detroit, MI USA
关键词
metastasis; carbohydrate; glycoprotein; lectin; galectin;
D O I
10.1023/A:1015535427597
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
This review focuses on the recent advances in investigations of the role of cell surface carbohydrates in tumor metastasis. It also summarizes the results of extensive studies of endogenous lectins, their structure, carbohydrate specificity and biological functions with the major emphasis on the significance of lectin-cell surface carbohydrate interactions in a metastatic process. Numerous data demonstrate that malignant transformation is associated with various and complex alterations in the glycosylation process. Some of these changes might provide a selective advantage for tumor cells during their progression to more invasive and metastatic phenotype. Cell glycosylation depends on the expression and function of various glycosyltransferases and glycosidases. Recently, transfection of genes encoding various glysosyltransferases gene in sense and antisense orientation helped to bring direct evidence that changes in cell surface carbohydrates are important for the metastatic behavior of tumor cells. Cell surface carbohydrates affect tumor cell interactions with normal cells or with the extracellular matrix during metastatic spread and growth. These interactions can be mediated via tumor cell carbohydrates and their binding proteins known as endogenous lectins. The family of the discovered endogenous lectins is rapidly expanding. The number of C-type lectins has reached 50 and at least 10 galectins have been identified. The biological significance of the endogenous lectins and their possible role in tumor growth and metastasis formation has started to unravel. Some lectins recognize the 'foreign' patterns of cell surface carbohydrates expressed by microorganisms and tumor cells, and play a role in innate and adaptive immunity. It was shown that lectins affect tumor cell survival, adhesion to the endothelium or extracellular matrix, as well as tumor vascularization and other processes that are crucial for metastatic spread and growth.
引用
收藏
页码:245 / 277
页数:33
相关论文
共 221 条
  • [1] Akahani S, 1997, CANCER RES, V57, P5272
  • [2] AKIYAMA SK, 1989, J BIOL CHEM, V264, P18011
  • [3] ALTEVOGT P, 1983, CANCER RES, V43, P5138
  • [4] Growth retardation and early death of beta-1,4-galactosyltransferase knockout mice with augmented proliferation and abnormal differentiation of epithelial cells
    Asano, M
    Furukawa, K
    Kido, M
    Matsumoto, S
    Umesaki, Y
    Kochibe, N
    Iwakura, Y
    [J]. EMBO JOURNAL, 1997, 16 (08) : 1850 - 1857
  • [5] GALECTINS - A FAMILY OF ANIMAL BETA-GALACTOSIDE-BINDING LECTINS
    BARONDES, SH
    CASTRONOVO, V
    COOPER, DNW
    CUMMINGS, RD
    DRICKAMER, K
    FEIZI, T
    GITT, MA
    HIRABAYASHI, J
    HUGHES, C
    KASAI, K
    LEFFLER, H
    LIU, FT
    LOTAN, R
    MERCURIO, AM
    MONSIGNY, M
    PILLAI, S
    POIRER, F
    RAZ, A
    RIGBY, PWJ
    RINI, JM
    WANG, JL
    [J]. CELL, 1994, 76 (04) : 597 - 598
  • [6] BARONDES SH, 1994, J BIOL CHEM, V269, P20807
  • [7] BERKE G, 1989, FUNDAMENTAL IMMUNOLO, P735
  • [8] INHIBITION OF LIVER METASTASIS IN MICE BY BLOCKING HEPATOCYTE LECTINS WITH ARABINOGALACTAN INFUSIONS AND D-GALACTOSE
    BEUTH, J
    KO, HL
    OETTE, K
    PULVERER, G
    ROSZKOWSKI, K
    UHLENBRUCK, G
    [J]. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 1987, 113 (01) : 51 - 55
  • [9] BEVAN MJ, 1975, J IMMUNOL, V114, P559
  • [10] BEZOUSKA K, 1991, J BIOL CHEM, V266, P11604