Peroxisome proliferator-activated receptor α-independent peroxisome proliferation

被引：19

作者：

Zhang, Xiuguo

Tanaka, Naoki

Nakajuna, Takero

Kamijo, Yuji

Gonzalez, Frank J.

Aoyama, Toshifumi

机构：

[1] Shinshu Univ, Dept Metab Regulat, Grad Sch Med, Matsumoto, Nagano 3908621, Japan

[2] Shinshu Univ, Dept Internal Med, Grad Sch Med, Matsumoto, Nagano 3908621, Japan

[3] NCI, Lab Metab, Bethesda, MD 20892 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2006年 / 346卷 / 04期

关键词：

peroxisome proliferator-activated receptor alpha; peroxisome proliferation; morphometry; dynamin-like protein 1;

D O I：

10.1016/j.bbrc.2006.06.042

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hepatic peroxisome proliferation, increases in the numerical and volume density of peroxisomes, is believed to be closely related to peroxisome proliferator-activated receptor alpha (PPAR alpha) activation; however, it remains unknown whether peroxisome proliferation depends absolutely on this activation. To verify occurrence of PPAR alpha-independent peroxisome proliferation, fenofibrate treatment was used. which was expected to significantly enhance PPAR alpha dependence in the assay system. Surprisingly, a novel type of PPAR alpha-independent peroxisome proliferation and enlargement was uncovered in PPAR alpha-null mice. The increased expression of dynamin-like protein 1, but not peroxisome biogenesis factor 11 alpha, might be associated with the PPAR alpha-independent peroxisome proliferation at least in part. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：1307 / 1311

页数：5

共 25 条

[1] CLONING OF A PROTEIN THAT MEDIATES TRANSCRIPTIONAL EFFECTS OF FATTY-ACIDS IN PREADIPOCYTES - HOMOLOGY TO PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS [J].