Mechanisms of cycloheximide-induced apoptosis in liver cells

被引：45

作者：

Alessenko, AV

Boikov, PY

Filippova, GN

Khrenov, AV

Loginov, AS

Makarieva, ED

机构：

[1] Institute of Biochemical Physics RAS, 4 Kosygin Str.

来源：

FEBS LETTERS | 1997年 / 416卷 / 01期

基金：

俄罗斯基础研究基金会;

关键词：

apoptosis; cycloheximide; sphingosine; c-myc gene expression; c-fos gene expression; c-jun gene expression; p53 gene expression;

D O I：

10.1016/S0014-5793(97)01161-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cycloheximide in sublethal doses caused apoptosis in liver cells in vivo, inducing c-myc, c-fos, c-jun and p53 genes and accumulation of sphingosine, a toxic product of the sphingomyelin cycle, These data support the hypothesis that continuous synthesis of labile protective proteins is required to restrain apoptosis in liver; sphingosine might be important in mediating cycloheximide-induced apoptosis as an endogenous modulator of protein kinase C activity. (C) 1997 Federation of European Biochemical Societies.

引用

页码：113 / 116

页数：4

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[2]

ALESENKO AV, 1994, BIOCHEMISTRY-MOSCOW+, V59, P807

[3]

BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911

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