Molecular interactions of neural chondroitin sulfate proteoglycans in the brain development

被引:149
作者
Oohira, A [1 ]
Matsui, F [1 ]
Tokita, Y [1 ]
Yamauchi, S [1 ]
Aono, S [1 ]
机构
[1] Aichi Human Serv Ctr, Inst Dev Res, Dept Perinatol & Neuroglycosci, Kasugai, Aichi 4800392, Japan
关键词
chondroitin sulfate; proteoglycan; neurocan; phosphacan; NGC; brain; development; brain injury;
D O I
10.1006/abbi.1999.1598
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Aggrecan family proteoglycans, phosphacan/RPTP zeta/beta, and neuroglycan C (NGC) are the major classes of chondroitin sulfate proteoglycan in the developing mammalian brain. A multidomain is a common structural feature of these proteoglycans which can interact with various molecules including growth factors, cell adhesion molecules, and extracellular matrix molecules. Individual proteoglycans are distributed in the developing brain in a distinct temporal and spatial pattern, suggesting that they are involved in distinct phases of the brain development through multiple molecular interactions, This review mainly summarizes recent studies on the involvement of these three classes of proteoglycan in cell-cell and cell-substratum interactions during the brain development, Their expressions and proposed functional roles in injured brains are also mentioned, In addition, this review briefly covers potential functions of other neural chondroitin sulfate proteoglycans such as decorin, testican, NG2 proteoglycan, and amyloid precursor protein (APP) in developing and injured brains. (C) 2000 Academic Press.
引用
收藏
页码:24 / 34
页数:11
相关论文
共 111 条
[1]  
AONO S, 2000, IN PRESS J BIOL CHEM, V275
[2]   Fibulin-1 is a ligand for the C-type lectin domains of aggrecan and versican [J].
Aspberg, A ;
Adam, S ;
Kostka, G ;
Timpl, R ;
Heinegård, D .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (29) :20444-20449
[3]   The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety [J].
Aspberg, A ;
Miura, R ;
Bourdoulous, S ;
Shimonaka, M ;
Heinegard, D ;
Schachner, M ;
Ruoslahti, E ;
Yamaguchi, Y .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (19) :10116-10121
[4]   The time course of loss of dopaminergic neurons and the gliotic reaction surrounding grafts of embryonic mesencephalon to the striatum [J].
Barker, RA ;
Dunnett, SB ;
Faissner, A ;
Fawcett, JW .
EXPERIMENTAL NEUROLOGY, 1996, 141 (01) :79-93
[5]  
Bonnet F, 1996, J BIOL CHEM, V271, P4373
[6]   Acute and long-lasting changes in extracellular-matrix chondroitin-sulphate proteoglycans induced by injection of chondroitinase ABC in the adult rat brain [J].
Brückner, G ;
Bringmann, A ;
Härtig, W ;
Köppe, G ;
Delpech, B ;
Brauer, K .
EXPERIMENTAL BRAIN RESEARCH, 1998, 121 (03) :300-310
[7]  
Butt AM, 1999, GLIA, V26, P84, DOI 10.1002/(SICI)1098-1136(199903)26:1<84::AID-GLIA9>3.3.CO
[8]  
2-C
[9]  
Canoll PD, 1996, J NEUROSCI RES, V44, P199, DOI 10.1002/(SICI)1097-4547(19960501)44:3<199::AID-JNR1>3.0.CO
[10]  
2-B