Difference of the liver and kidney in glycine conjugation of ortho-substituted benzoic acids

被引：21

作者：

Kasuya, F ^{[1
]}

Yamaoka, Y ^{[1
]}

Osawa, E ^{[1
]}

Igarashi, K ^{[1
]}

Fukui, M ^{[1
]}

机构：

[1] Kobe Gakuin Univ, Fac Pharmaceut Sci, Nishi Ku, Kobe, Hyogo 6512180, Japan

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 2000年 / 125卷 / 01期

关键词：

glycine conjugation; kidney; liver; mouse; ortho-substituted benzoic acids; structure-metabolism relationship;

D O I：

10.1016/S0009-2797(99)00163-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The relative importance of the liver and kidney for glycine conjugation of ortho-substituted benzoic acids was investigated. Glycine conjugation of ortho-substituted benzoic acids was investigated in mouse liver and kidney mitochondria. The extent of glycine conjugation of benzoic acids with the halogen group decreased in the order F > Cl > Br > I. The conjugation of salicylic acid with glycine took place in only the kidney. 2-Methoxybenzoic acid exhibited no activity in the liver and kidney. The difference in glycine conjugation of ortho-substituted benzoic acids was observed between liver and kidney. The kidney was more active in glycine conjugation of ortho-substituted acids than the liver. In addition, the relationship between glycine conjugation and the chemical structure of ortho-substituted acids was examined in the liver and kidney. The size of the substituent had a far greater influence over glycine conjugation in the liver and kidney. Glycine conjugation was also dependent on the substituent electronegativity. It may be important that the substrates undergoing glycine conjugation contain a flat region coplanar to the carboxylate group. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：39 / 50

页数：12

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