IL-2-inducible T-cell kinase (ITK) finds another (dance) partner ... TFII-I

被引：5

作者：

August, Avery ^{[1
]}

机构：

[1] Penn State Univ, Dept Vet & Biomed Sci, Ctr Mol Immunol & Infect Dis, University Pk, PA 16802 USA

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2009年 / 39卷 / 09期

关键词：

ITK; T-cell signaling; Tec kinase; TFII-I; BRUTONS TYROSINE KINASE; TEC FAMILY; REGULATES INDUCTION; IGE PRODUCTION; CALCIUM-ENTRY; ACTIVE ITK; ACTIVATION; DEFICIENT; GAMMA; MICE;

D O I：

10.1002/eji.200939813

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The signals that regulate T-cell activation have been studied for some time. We know that upon interaction with antigen/MHC complex, the TCR triggers the activation of a number of kinases, including tyrosine and serine/threonine kinases. The Tec family kinase IL-2-inducible T-cell kinase (ITK) plays a role in this response, but the signaling pathways that ITK regulates are less well known. Even less known are the binding partners and substrates of ITK. A paper in this issue of the European Journal of Immunology extends our knowledge on the subject by showing that ITK interacts with the transcriptional regulator TFII-I. The implications of this finding are discussed.

引用

页码：2354 / 2357

页数：4

共 43 条

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