Clonostachin, a novel peptaibol that inhibits platelet aggregation

被引：25

作者：

Chikanishi, T ^{[1
]}

Hasumi, K ^{[1
]}

Harada, T ^{[1
]}

Kawasaki, N ^{[1
]}

Endo, A ^{[1
]}

机构：

[1] TOKYO NOKO UNIV, DEPT APPL BIOL SCI, FUCHU, TOKYO 183, JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1997年 / 50卷 / 02期

关键词：

D O I：

10.7164/antibiotics.50.105

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A novel peptaibol, designated clonostachin, was isolated from cultures of Clonostachys sp. F5898 by HP-20 and silica gel column chromatographies and reverse-phase HPLC. The structure of clonostachin was determined by Edman and chemical degradations, positive ion FAB-MS, EI-MS, and NMR analyses. Clonostachin was a linear tetradecapeptide with an N-terminal acetyl group and a C-terminal sugar alcohol. Clonostachin inhibited ADP-induced aggregation of human platelets by 80% at 150 mu M.

引用

页码：105 / 110

页数：6

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