Worsening of an immune thrombocytopenia during monotherapy with levetiracetam

被引：10

作者：

Hartmann, H

Schumacher, U

Seeck, M

机构：

[1] Kantonsspital Munsterlingen, Klin Kinder & Jugendliche, Munsterlingen, Switzerland

[2] Hop Cantonal Univ Geneva, Lab Explorat Prechirurg Epilepsies, Geneva, Switzerland

来源：

AKTUELLE NEUROLOGIE | 2002年 / 29卷 / 09期

关键词：

D O I：

10.1055/s-2002-35268

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A 16-year old girl suffering from epilepsy with complex-partial seizures developed a chronic immune thrombocytopenia during treatment with valproic acid, oxcarbacepine and phenytoin. After discontinuation of all antiepileptic drugs her thrombocyte count rose. However, following the initiation of a monotherapy with levetiracetam, her thrombocytopenia worsened and she developed clinically relevant bleeds. Therapy with 7-s-immunoglobulines and methylprednisolone only led to a limited response. Therefore treatment with an anti-CD 20-antibody was begun. As most antiepileptic drugs, levetiracetam may be associated with immune thrombocytopenia.

引用

页码：467 / 468

页数：2

共 5 条

[1]

Brown J J, 1986, Pediatr Neurol, V2, P99, DOI 10.1016/0887-8994(86)90064-0

[2] THROMBOCYTOPENIA SECONDARY TO HIGH VALPROATE LEVELS IN CHILDREN WITH EPILEPSY [J].