Fos in locus coeruleus neurons following audiogenic seizure in the genetically epilepsy-prone rat: comparison to electroshock and pentylenetetrazol seizure models

被引：19

作者：

Eells, JB

Clough, RW

Browning, RA

Jobe, PC

机构：

[1] SO ILLINOIS UNIV,SCH MED,DEPT ANAT,CARBONDALE,IL 62901

[2] SO ILLINOIS UNIV,SCH MED,DEPT PHYSIOL,CARBONDALE,IL 62901

[3] UNIV ILLINOIS,COLL MED,DEPT BIOMED & THERAPEUT SCI,PEORIA,IL 61656

来源：

NEUROSCIENCE LETTERS | 1997年 / 233卷 / 01期

关键词：

epilepsy; norepinephrine; immediate early gene expression; c-Fos;

D O I：

10.1016/S0304-3940(97)00611-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Seizures in genetically epilepsy-prone rats (GEPRs) may result from hypoactivity of locus coeruleus (LC) neurons during seizures. This study examined Fos-like-immunoreactivity (FLI) in the LC following audiogenic seizures in two strains of GEPRs (GEPR-9s and -3s), and following pentylenetetrazol (PTZ) or maximal electroshock seizures (MES) in normal rats. After tonic seizure, GEPR-9s showed an identical LC-FLI response to that of normal rats following tonic seizures induced by either PTZ or MES. GEPR-3s, having clonic seizures, had less FLI in the LC. Therefore, stimulus-transcription coupling in the GEPR LC is apparently normo-typic in its FLI response to seizure and thus is not likely the root cause of NE abnormalities in this seizure model. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：21 / 24

页数：4

共 18 条

[1] KINDLING ANTAGONISM - A ROLE FOR HINDBRAIN NOREPINEPHRINE IN THE DEVELOPMENT OF SITE SUPPRESSION FOLLOWING CONCURRENT, ALTERNATE STIMULATION [J].