Preclinical evaluation of the anti proliferative potential of ST1571 in Hodgkin's disease

被引：8

作者：

Re, D

Wickenhauser, C

Ahmadi, T

Buchdunger, E

Kochanek, M

Diehl, V

Wolf, J

机构：

[1] Univ Cologne, Dept Internal Med 1, D-50931 Cologne, Germany

[2] Univ Cologne, Inst Pathol, D-50931 Cologne, Germany

[3] Novartis Pharma AG, Oncol Res, CH-4002 Basel, Switzerland

来源：

BRITISH JOURNAL OF CANCER | 2002年 / 86卷 / 08期

关键词：

Hodgkin and Reed Sternberg cells; ST1571; c-kit (CD117);

D O I：

10.1038/sj.bjc.6600243

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

ST\57\ is a selective tyrosine kinase inhibitor with proven therapeutic potential in malignancies expressing c-kit. A strong c-kit and stern cell factor expression was detected in the Hodgkin and Reed Sternberg cell line L 1236, but not in 20 primary cases of classical Hodgkin's disease, Proliferation of L1236 cells was neither affected by addition of stem cell factor nor by neutralising anti-stem cell factor antibodies or ST1571. Results suggest that patients with Hodgkin's disease may not benefit from therapy with ST1571. (C) 2002 Cancer Research UK.

引用

收藏

页码：1333 / 1335

页数：3

相关论文

共 15 条

[1]

Buchdunger E, 2000, J PHARMACOL EXP THER, V295, P139

[2]

Cossman J, 1998, LAB INVEST, V78, P229

[3] RECENT RESULTS ON THE BIOLOGY OF HODGKIN AND REED-STERNBERG CELLS .2. CONTINUOUS CELL-LINES [J].

DREXLER, HG .

LEUKEMIA & LYMPHOMA, 1993, 9 (1-2) :1-25

[4] RECENT RESULTS ON THE BIOLOGY OF HODGKIN AND REED-STERNBERG CELLS .1. BIOPSY MATERIAL [J].

DREXLER, HG .

LEUKEMIA & LYMPHOMA, 1992, 8 (4-5) :283-313

[5] Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells [J].

Druker, BJ ;

Tamura, S ;

Buchdunger, E ;

Ohno, S ;

Segal, GM ;

Fanning, S ;

Zimmermann, J ;

Lydon, NB .

NATURE MEDICINE, 1996, 2 (05) :561-566

[6] Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. [J].

Druker, BJ ;

Talpaz, M ;

Resta, DJ ;

Peng, B ;

Buchdunger, E ;

Ford, JM ;

Lydon, NB ;

Kantarjian, H ;

Capdeville, R ;

Ohno-Jones, S ;

Sawyers, CL .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (14) :1031-1037

[7] Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor [J].

Heinrich, MC ;

Griffith, DJ ;

Druker, BJ ;

Wait, CL ;

Ott, KA ;

Zigler, AJ .

BLOOD, 2000, 96 (03) :925-932

[8] Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors [J].

Hirota, S ;

Isozaki, K ;

Moriyama, Y ;

Hashimoto, K ;

Nishida, T ;

Ishiguro, S ;

Kawano, K ;

Hanada, M ;

Kurata, A ;

Takeda, M ;

Tunio, GM ;

Matsuzawa, Y ;

Kanakura, Y ;

Shinomura, Y ;

Kitamura, Y .

SCIENCE, 1998, 279 (5350) :577-580

[9] Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor. [J].

Joensuu, H ;

Roberts, PJ ;

Sarlomo-Rikala, M ;

Andersson, LC ;

Tervahartiala, P ;

Tuveson, D ;

Silberman, SL ;

Capdeville, R ;

Dimitrijevic, S ;

Druker, B ;

Demetri, GD .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (14) :1052-1056

[10] The origin of Hodgkin and Reed/Sternberg cells in Hodgkin's disease [J].

Küppers, R ;

Rajewsky, K .

ANNUAL REVIEW OF IMMUNOLOGY, 1998, 16 :471-493