Alzheimer disease risk associated with APOE4 is modified by STH gene polymorphism

被引：15

作者：

Seripa, D ^{[1
]}

Matera, MG

D'Andrea, RP

Gravina, C

Masullo, C

Daniele, A

Bizzarro, A

Rinaldi, M

Antuono, P

Wekstein, DR

Dal Forno, G

Fazio, VM

机构：

[1] Padre Pio da Pietrelcina Fdn, IRCCS Casa Sollievo Sofferenza, Lab Gene Therapy, I-71013 San Giovanni Rotondo, FG, Italy

[2] Catholic Univ, Sch Med, Inst Neurol, Rome, Italy

[3] CNR, Inst Neurol & Mol Med, Mol Med Sect, Gene Med Div, Rome, Italy

[4] Interdisciplinary Ctr Biomed Res, Lab Mol Med & Biotechnol, Rome, Italy

[5] Med Coll Wisconsin, Dept Neurol, Milwaukee, WI 53226 USA

[6] Univ Kentucky, Alzheimers Dis Res Ctr, Lexington, KY USA

[7] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

来源：

NEUROLOGY | 2004年 / 62卷 / 09期

关键词：

D O I：

10.1212/01.WNL.0000125693.59817.31

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The association of the STH gene polymorphism with Alzheimer disease ( AD) is debated. In the analysis of two genetically and diagnostically distinct groups of Alzheimer patients from the USA and Italy, the authors did not find an association with the STH polymorphism. However, the APOE-4-associated risk of AD greatly increased if the STH-G allele was also present. The STH-G allele appears to be a risk modifier for AD.

引用

页码：1631 / 1633

页数：3

共 7 条

[1] A polymorphic gene nested within an intron of the tau gene:: Implications for Alzheimer's disease [J].

Conrad, C ;

Vianna, C ;

Freeman, M ;

Davies, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (11) :7751-7756

[2] Alzheimer disease [J].

Cummings, JL ;

Cole, G .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 287 (18) :2335-2338

[3] DIAGNOSIS OF ALZHEIMERS-DISEASE [J].

KHACHATURIAN, ZS .

ARCHIVES OF NEUROLOGY, 1985, 42 (11) :1097-1104

[4]

MASULLO C, 1988, DEMENT GERIATR COGN, V9, P121

[5]

MCKHANN G, 1984, NEUROLOGY, V34, P939, DOI 10.1212/WNL.34.7.939

[6] The molecular and genetic basis of AD: The end of the beginning - The 2000 Wartenberg lecture [J].

Rosenberg, RN .

NEUROLOGY, 2000, 54 (11) :2045-2054

[7]

Schneider S., 2000, ARLEQUIN VER 2 001 S

← 1 →