Regioselectively carbamoylated polysaccharides for the separation of enantiomers in high-performance liquid chromatography

被引:16
作者
Chassaing, C [1 ]
Thienpont, A [1 ]
Soulard, MH [1 ]
Felix, G [1 ]
机构
[1] ENSCPB,F-33402 TALENCE,FRANCE
关键词
enantiomer separation; stationary phases; LC; polysaccharides; benzodiazepines;
D O I
10.1016/S0021-9673(97)00553-0
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The chromatographic behavior of new chiral stationary phases (CSPs) based on mixed substituted cellulose, amylose or amylopectin is reported. Most CSPs have a 3,5-dimethylphenylcarbamate at the 2 and 3 positions of the glucose unit and either an (R)-, (S)- or (RS)-phenylethylcarbamate at the 6 position. This study shows that configuration of the phenylethylcarbamate at the 6 position largely influences the chiral recognition depending upon the polysaccharide studied. Some of the new CSPs exhibit a better enantioselective power for several racemates as compared to the corresponding symmetrical substituted polysaccharides CSPs. The resolution of some benzodiazepines is also reported. (C) 1997 Elsevier Science B.V.
引用
收藏
页码:13 / 21
页数:9
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