共 54 条
BCR-mediated uptake of antigen linked to TLR9 ligand stimulates B-cell proliferation and antigen-specific plasma cell formation
被引:119
作者:

Eckl-Dorna, Julia
论文数: 0 引用数: 0
h-index: 0
机构:
Lincolns Inn Fields Labs, Canc Res UK London Res Inst, Lymphocyte Interact Lab, London WC2A 3PX, England Lincolns Inn Fields Labs, Canc Res UK London Res Inst, Lymphocyte Interact Lab, London WC2A 3PX, England

Batista, Facundo D.
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h-index: 0
机构:
Lincolns Inn Fields Labs, Canc Res UK London Res Inst, Lymphocyte Interact Lab, London WC2A 3PX, England Lincolns Inn Fields Labs, Canc Res UK London Res Inst, Lymphocyte Interact Lab, London WC2A 3PX, England
机构:
[1] Lincolns Inn Fields Labs, Canc Res UK London Res Inst, Lymphocyte Interact Lab, London WC2A 3PX, England
来源:
关键词:
TOLL-LIKE RECEPTORS;
CLASS SWITCH RECOMBINATION;
ANTIBODY-RESPONSES;
CLASS-II;
IN-VIVO;
GERMINAL-CENTERS;
TRANSGENIC MICE;
BACTERIAL-DNA;
T-CELLS;
CPG-DNA;
D O I:
10.1182/blood-2008-10-185421
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
The activation of Toll-like receptor 9 (TLR9) expressed within B cells is associated with enhanced humoral immunity. However the role of TLR9 in the stimulation of B-cell responses, and more specifically in shaping the outcome of B-cell differentiation, remains unclear. Here, we observed that immunization with the TLR9 agonist CpG linked to protein antigen gave rise to enhanced production of antigen-specific class-switched antibodies in vivo. Unlike dendritic cells, B cells are unable to acquire these conjugates by macropinocytosis and instead depend on uptake through a signaling-competent B-cell receptor (BCR), provided the overall BCR-antigen avidity exceeds a defined threshold. The resultant stimulation of intrinsic TLR9 leads to enhanced antigen-specific B-cell proliferation and differentiation to form extrafollicular plasma cells. Thus, the direct conjugation of antigen and CpG reveals a mechanism that may operate during the initiation of primary immune responses, and may prove useful as a strategy for the design of adjuvants suitable for vaccinations. (Blood. 2009;113:3969-3977)
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页码:3969 / 3977
页数:9
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