Gene-Gene Interactions in Inflammatory Bowel Disease: Biological and Clinical Implications

被引：13

作者：

Achkar, Jean-Paul ^{[1
,2
]}

Fiocchi, Claudio ^{[1
,2
]}

机构：

[1] Cleveland Clin, Inst Digest Dis, Dept Gastroenterol & Hepatol, Cleveland, OH 44195 USA

[2] Cleveland Clin, Lerner Res Inst, Dept Pathobiol, Cleveland, OH 44195 USA

来源：

AMERICAN JOURNAL OF GASTROENTEROLOGY | 2009年 / 104卷 / 07期

关键词：

GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY; EPISTASIS; LOCI;

D O I：

10.1038/ajg.2009.179

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

The results of recently completed genome-wide association studies have advanced knowledge of inflammatory bowel disease (IBD) genetics, including the identification of over 30 genes or loci associated with Crohn's disease (CD). The possibility of interactions between genes, referred to by the term epistasis, needs to be carefully considered as both genetic and functional studies in IBD move forward. We review a paper in this issue of the Journal that reports evidence of epistasis in CD, and we discuss important issues that arise when trying to determine whether there is indeed interaction between genes and what their potential implications for disease pathogenesis and clinical outcome might be.

引用

页码：1734 / 1736

页数：3

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