Enantioselective syntheses of tremulenediol A and tremulenolide A

被引：29

作者：

Ashfeld, Brandon L. ^{[1
]}

Martin, Stephen F. ^{[1
]}

机构：

[1] Univ Texas, Dept Chem & Biochem, Austin, TX 78712 USA

来源：

TETRAHEDRON | 2006年 / 62卷 / 45期

关键词：

D O I：

10.1016/j.tet.2006.05.087

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise entry to the skeleton of the tremulane sesquiterpenes is described that culminated in the first enantioselective syntheses of tremulenediol A and tremulenolide A. The approach features a series of efficient transition metal-catalyzed reactions commencing with an enantioselective rhodium(II)-catalyzed intramolecular cyclopropanation followed by a regioselective allylic alkylation and a diastereoseleclive rhodium(l)-catalyzed [5+2] cycloaddition. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：10497 / 10506

页数：10

共 24 条

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