Association of CTLA4 but not ICOS polymorphisms with type 1 diabetes in two populations with different disease rates

被引：31

作者：

Douroudis, Konstantinos ^{[1
]}

Laine, Antti-Pekka ^{[2
]}

Heinonen, Mirkka ^{[2
]}

Hermann, Robert ^{[2
]}

Lipponen, Kati ^{[2
]}

Veijola, Riitta ^{[3
]}

Simell, Olli ^{[4
]}

Knip, Mikael ^{[5
,6
]}

Uibo, Raivo ^{[1
]}

Ilonen, Jorma ^{[2
,7
]}

Kisand, Kalle ^{[1
]}

机构：

[1] Univ Tartu, IGMP, Immunol Grp, EE-50090 Tartu, Estonia

[2] Univ Turku, Imunogenet Lab, Turku, Finland

[3] Univ Oulu, Dept Pediat, SF-90100 Oulu, Finland

[4] Univ Turku, Dept Pediat, Turku, Finland

[5] Univ Helsinki, Hosp Children & Adolescents, Helsinki, Finland

[6] Tampere Univ Hosp, Dept Pediat, Tampere, Finland

[7] Univ Kuopio, Dept Clin Microbiol, FIN-70211 Kuopio, Finland

来源：

HUMAN IMMUNOLOGY | 2009年 / 70卷 / 07期

基金：

英国医学研究理事会;

关键词：

CTLA-4; ICOS; Type; 1; diabetes; GRAVES-DISEASE; GENE POLYMORPHISM; SUSCEPTIBILITY;

D O I：

10.1016/j.humimm.2009.04.023

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and inducible T-cell co-stimulator (ICOS) genes are important mediators off-cell activation in autoimmune diseases. The aim of the current study was to assess the impact of CTLA-4 and ICOS genes on the susceptibility to type I diabetes among two populations with different disease incidence rates. Three single nucleotide polymorphisms (SNPs) within the CTLA-4 region (+49A/G, CT60A/G, CrBC217_1C/T) and two SNPs within the ICOS region (CTIC154_1C/T, CTIC159 C/G) were genotyped in 955 control subjects and 574 diabetic patients of Estonian and Finnish descent. The current study confirms the involvement of the CTLA-4 but not the ICOS gene in susceptibility to type I diabetes. However, the risk alleles and the defined main risk haplotype were more common in the Finnish controls compared with the Estonians, indicating that this gene locus might also be one of the contributing factors to the higher disease incidence in Finland. (C) 2009 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

引用

页码：536 / 539

页数：4

共 18 条

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