Disorders related to peroxisomal membranes

被引：8

作者：

Gärtner, J ^{[1
]}

机构：

[1] Univ Dusseldorf, Dept Paediat, D-40225 Dusseldorf, Germany

来源：

JOURNAL OF INHERITED METABOLIC DISEASE | 2000年 / 23卷 / 03期

关键词：

D O I：

10.1023/A:1005636113499

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The peroxisome is a ubiquitous, subcellular organelle participating in a diverse array of metabolic pathways. The peroxisomal membrane and its components play a key role in organelle assembly and functions. Disorders related to peroxisomal membranes are the peroxisome biogenesis disorders and X-linked adrenoleukodystrophy. Identification and functional characterization of these disease genes is proceeding at rapid pace helped immeasurably by work in various yeast model systems. The ultimate goal is to elucidate how the encoded proteins interact to produce apparently normal and functioning peroxisomes. The achievement of this goal will lead to a better understanding of disease pathogenesis and hopefully open therapeutic options.

引用

页码：264 / 272

页数：9

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