Type 2 Diabetes Susceptibility Gene TCF7L2 and Its Role in β-Cell Function

被引：47

作者：

Gloyn, Anna L. ^{[1
]}

Braun, Matthias ^{[1
]}

Rorsman, Patrik ^{[1
]}

机构：

[1] Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England

来源：

DIABETES | 2009年 / 58卷 / 04期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

INSULIN-SECRETION; REPLICATION; VARIANTS; RISK;

D O I：

10.2337/db09-0099

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：800 / 802

页数：3

共 17 条

[1] Fast exocytosis with few Ca2+ channels in insulin-secreting mouse pancreatic B cells [J].

Barg, S ;

Ma, XS ;

Eliasson, L ;

Galvanovskis, J ;

Göpel, SO ;

Obermüller, S ;

Platzer, J ;

Renström, E ;

Trus, M ;

Atlas, D ;

Striessnig, J ;

Rorsman, P .

BIOPHYSICAL JOURNAL, 2001, 81 (06) :3308-3323

[2] TCF7L2 variation predicts hyperglycentia incidence in a French general population -: The Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study [J].

Cauchi, Stephane ;

Meyre, David ;

Choquet, Helene ;

Dina, Christian ;

Born, Catherine ;

Marre, Michel ;

Balkau, Beverley ;

Froguel, Philippe .

DIABETES, 2006, 55 (11) :3189-3192

[3] Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish -: Replication and evidence for a role in both insulin secretion and insulin resistance [J].

Damcott, Coleen M. ;

Pollin, Toni I. ;

Reinhart, Laurie J. ;

Ott, Sandra H. ;

Shen, Haiqing ;

Silver, Kristi D. ;

Mitchell, Braxton D. ;

Shuldiner, Alan R. .

DIABETES, 2006, 55 (09) :2654-2659

[4] Genetics: how the UKPDS contributed to determining the genetic landscape of Type 2 diabetes [J].

Gloyn, A. L. ;

McCarthy, M. I. .

DIABETIC MEDICINE, 2008, 25 :35-40

[5] Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes [J].

Grant, SFA ;

Thorleifsson, G ;

Reynisdottir, I ;

Benediktsson, R ;

Manolescu, A ;

Sainz, J ;

Helgason, A ;

Stefansson, H ;

Emilsson, V ;

Helgadottir, A ;

Styrkarsdottir, U ;

Magnusson, KP ;

Walters, GB ;

Palsdottir, E ;

Jonsdottir, T ;

Gudmundsdottir, T ;

Gylfason, A ;

Saemundsdottir, J ;

Wilensky, RL ;

Reilly, MP ;

Rader, DJ ;

Bagger, Y ;

Christiansen, C ;

Gudnason, V ;

Sigurdsson, G ;

Thorsteinsdottir, U ;

Gulcher, JR ;

Kong, A ;

Stefansson, K .

NATURE GENETICS, 2006, 38 (03) :320-323

[6] Association analysis of 6,736 UK subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk [J].

Groves, Christopher J. ;

Zeggini, Eleftheria ;

Minton, Jayne ;

Frayling, Timothy M. ;

Weedon, Michael N. ;

Rayner, Nigel W. ;

Hitman, Graham A. ;

Walker, Mark ;

Wiltshire, Steven ;

Hattersley, Andrew T. ;

McCarthy, Mark I. .

DIABETES, 2006, 55 (09) :2640-2644

[7] The Wnt Signaling Pathway Effector TCF7L2 and Type 2 Diabetes Mellitus [J].

Jin, Tianru ;

Liu, Ling .

MOLECULAR ENDOCRINOLOGY, 2008, 22 (11) :2383-2392

[8] Assessing the Combined Impact of 18 Common Genetic Variants of Modest Effect Sizes on Type 2 Diabetes Risk [J].

Lango, Hana ;

Palmer, Colin N. A. ;

Morris, Andrew D. ;

Zeggini, Eleftheria ;

Hattersley, Andrew T. ;

McCarthy, Mark I. ;

Frayling, Timothy M. ;

Weedon, Michael N. .

DIABETES, 2008, 57 (11) :3129-3135

[9] Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes [J].

Lyssenko, Valeriya ;

Lupi, Roberto ;

Marchetti, Piero ;

Del Guerra, Silvia ;

Orho-Melander, Marju ;

Almgren, Peter ;

Sjogren, Marketa ;

Ling, Charlotte ;

Eriksson, Karl-Fredrik ;

Lethagen, Asa-Linda ;

Mancarella, Rita ;

Berglund, Goran ;

Tuomi, Tiinamaija ;

Nilsson, Peter ;

Del Prato, Stefano ;

Groop, Leif .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (08) :2155-2163

[10] Type 2 diabetes: new genes, new understanding [J].

Prokopenko, Inga ;

McCarthy, Mark I. ;

Lindgren, Cecilia M. .

TRENDS IN GENETICS, 2008, 24 (12) :613-621

← 1 2 →