CD45 tyrosine phosphatase inhibitory components from Aspergillus niger

被引：17

作者：

Alvi, KA ^{[1
]}

Nair, BG ^{[1
]}

Rabenstein, J ^{[1
]}

Davis, G ^{[1
]}

Baker, DD ^{[1
]}

机构：

[1] MDS Panlabs, Bothell, WA 98011 USA

来源：

JOURNAL OF ANTIBIOTICS | 2000年 / 53卷 / 02期

关键词：

D O I：

10.7164/antibiotics.53.110

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two inhibitors of CD45 tyrosine phosphatase, dihydrocarolic acid (1) and penitricin D (2), were isolated from a fermentation broth of the fungus Aspergillus niger and purified by HSCCC (high speed countercurrent chromatography) followed by HPLC. The structures were determined by NMR. The inhibitory activities of both compounds were specific to tyrosine phosphatases.

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页码：110 / 113

页数：4

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