Voriconazole (UK-109,496) inhibits the growth and alters the morphology of fluconazole-susceptible and -resistant Candida species

被引：59

作者：

Belanger, P

Nast, CC

Fratti, R

Sanati, H

Ghannoum, M

机构：

[1] UNIV HOSP CLEVELAND,CTR MED MYCOL,MYCOL REFERENCE LAB,CLEVELAND,OH 44106

[2] UNIV CALIF LOS ANGELES,HARBOR MED CTR,DIV INFECT DIS,TORRANCE,CA 90509

[3] CEDARS SINAI MED CTR,DEPT PATHOL,LOS ANGELES,CA 90048

[4] CASE WESTERN RESERVE UNIV,DEPT DERMATOL,CLEVELAND,OH 44106

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 08期

关键词：

D O I：

10.1128/AAC.41.8.1840

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The effects of voriconazole on the growth, ultrastructure, and leakage of cytoplasmic materials of Candida species were investigated, MIC data showed that voriconazole was more active than fluconazole. Exposure of yeast to voriconazole caused growth inhibition, cell wall thinning, and cell membrane degradation. Neither cell collapse nor release of cytoplasmic materials was observed in the treated cells.

引用

页码：1840 / 1842

页数：3

共 9 条

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