Helping Patients Make Informed Choices About Probiotics: A Need for Research

被引:22
作者
Sharp, Richard R. [1 ]
Achkar, Jean-Paul [2 ]
Brinich, Margaret A. [1 ]
Farrell, Ruth M. [1 ]
机构
[1] Cleveland Clin, Dept Bioeth, Cleveland, OH 44195 USA
[2] Cleveland Clin, Dept Gastroenterol & Hepatol, Cleveland, OH 44195 USA
基金
美国国家卫生研究院;
关键词
IRRITABLE-BOWEL-SYNDROME; HERB-DRUG INTERACTIONS; DOUBLE-BLIND; SACCHAROMYCES-BOULARDII; ALTERNATIVE MEDICINE; CLINICAL-PRACTICE; COMPLEMENTARY; BIFIDOBACTERIUM; PREBIOTICS; DISEASE;
D O I
10.1038/ajg.2008.68
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Applications of probiotics in the treatment of gastrointestinal disorders are gaining acceptance among patients, despite evidence that probiotics can present substantial health risks, particularly for patients who are immunocompromised or seriously ill. Patients will likely formulate their attitudes and beliefs about probiotic therapies with reference to interpretive frameworks that compare probiotics with more familiar therapeutic modalities, including complementary and alternative medicines, pharmacological therapies, and gene-transfer technologies. Each of these frameworks highlights a different set of benefit-to-risk considerations regarding probiotic usage and reinforces extreme characterizations of both the therapeutic promise and peril of probiotics. Considerable effort may be required to help patients make informed choices about probiotic therapies.
引用
收藏
页码:809 / 813
页数:5
相关论文
共 50 条
[1]   Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial [J].
Besselink, Marc G. H. ;
van Santvoort, Hjalmar C. ;
Buskens, Erik ;
Boermeester, Marja A. ;
van Goor, Harry ;
Timmerman, Harro M. ;
Nieuwenhuijs, Vincent B. ;
Bollen, Thomas L. ;
van Ramshorst, Bert ;
Witteman, Ben J. M. ;
Rosman, Camiel ;
Ploeg, Rutger J. ;
Brink, Menno A. ;
Schaapherder, Alexander F. M. ;
Dejong, Cornelis H. C. ;
Wahab, Peter J. ;
van Laarhoven, Cees J. H. M. ;
van der Harst, Erwin ;
van Eijck, Casper H. J. ;
Cuesta, Miguel A. ;
Akkermans, Louis M. A. ;
Gooszen, Hein G. .
LANCET, 2008, 371 (9613) :651-659
[2]   Prescript-assist™ probiotic-prebiotic treatment for irritable bowel syndrome:: A methodologically oriented, 2-week, randomized, placebo-controlled, double-blind clinical study [J].
Bittner, AC ;
Croffut, RM ;
Stranahan, MC .
CLINICAL THERAPEUTICS, 2005, 27 (06) :755-761
[3]   Probiotic use in clinical practice: what are the risks? [J].
Boyle, Robert J. ;
Robins-Browne, Roy M. ;
Tang, Mimi L. K. .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2006, 83 (06) :1256-1264
[4]  
Cui HH, 2004, WORLD J GASTROENTERO, V10, P1521
[5]   Explaining risks: turning numerical data into meaningful pictures [J].
Edwards, A ;
Elwyn, G ;
Mulley, A .
BMJ-BRITISH MEDICAL JOURNAL, 2002, 324 (7341) :827-830
[6]   Advising patients who seek alternative medical therapies [J].
Eisenberg, DM .
ANNALS OF INTERNAL MEDICINE, 1997, 127 (01) :61-69
[7]   Perceptions about complementary therapies relative to conventional therapies among adults who use both: Results from a national survey [J].
Eisenberg, DM ;
Kessler, RC ;
Van Rompay, MI ;
Kaptchuk, TJ ;
Wilkey, SA ;
Appel, S ;
Davis, RB .
ANNALS OF INTERNAL MEDICINE, 2001, 135 (05) :344-351
[8]  
*FAO UN WHO, REP JOINT FAO WHO EX
[9]  
FEDORAK R, 2006, US GASTROENTEROL REV, V1, P1
[10]   Probiotics and prebiotics in gastrointestinal disorders [J].
Fedorak, RN ;
Madsen, KL .
CURRENT OPINION IN GASTROENTEROLOGY, 2004, 20 (02) :146-155