Protein kinase CK2: a new view of an old molecular complex

被引：97

作者：

Filhol, O

Martiel, JL

Cochet, C ^{[1
]}

机构：

[1] CEA, INSERM, EMI 104, Dept Reponse & Dyanm Cellulaire, F-38054 Grenoble, France

[2] Fac Med, TIMC, CNRS, F-38706 La Tronche, France

来源：

EMBO REPORTS | 2004年 / 5卷 / 04期

关键词：

CK22; dynamic subunit interaction; heterotetrameric complex;

D O I：

10.1038/sj.embor.7400115

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein kinase CK2 (formerly known as casein kinase II) has been viewed traditionally as a stable heterotetrameric complex, but new analytical techniques are bringing a different picture into focus. The transient nature of this complex has been highlighted by the elucidation of its structure. Furthermore, analysis of the spatiotemporal organization of individual CK2 subunits in living cells has shown that they are dynamic and that they integrate into different multimolecular assemblies. These new studies give an additional dimension to the challenge of determining the cellular regulation of this protein kinase.

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页码：351 / 355

页数：5

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